Biokinetics and clearance of inhaled gold ultrasmall-in-nano architectures,Nanoscale Advances

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Biokinetics and clearance of inhaled gold ultrasmall-in-nano architectures
Nanoscale Advances ( IF 4.6 ) Pub Date : 2020-07-22 , DOI: 10.1039/d0na00521e
Ana Katrina Mapanao _{1,

2} , Giulia Giannone _{1,

2} , Maria Summa ₃ , Maria Laura Ermini ₁ , Agata Zamborlin _{1,

2} , Melissa Santi ₁ , Domenico Cassano ₁ , Rosalia Bertorelli ₃ , Valerio Voliani ₁

Affiliation

Among an organism's entry portals, the respiratory tract is one of the most promising routes for non-invasive administration of therapeutics for local and systemic delivery. On the other hand, it is the subtlest to protect from environmental pollution and microbial occurrences. Here, the biokinetics, distribution, and clearance trends of gold ultrasmall-in-nano architectures administered through a single intranasal application have been quantitatively evaluated. Apart from reaching the lung parenchyma, the (bio)degradable nano-architectures are able to translocate as well to secondary organs and be almost completely excreted within 10 days. These findings further support the clinical relevance of plasmonic nanomaterials for oncology and infectious disease treatment and management. Notably, this investigation also provides crucial information regarding the associated risks as a consequence of the pulmonary delivery of nanoparticles.

中文翻译：

吸入金超小纳米结构的生物动力学和清除

在生物体的入口中，呼吸道是用于局部和全身递送的非侵入性给药治疗的最有希望的途径之一。另一方面，保护免受环境污染和微生物发生是最微妙的。在这里，定量评估了通过单一鼻内应用管理的金超小纳米结构的生物动力学、分布和清除趋势。除了到达肺实质外，（生物）可降解的纳米结构还能够转移到次级器官，并在 10 天内几乎完全排出体外。这些发现进一步支持了等离子体纳米材料在肿瘤学和传染病治疗和管理中的临床相关性。尤其，

更新日期：2020-09-16

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