The proportion of assisted reproductive technology (ART)-conceived livebirths of patients with imprinting disorders (IDs) is higher than that of the general population. Whether this is due to ART or confounding effects of advanced parental age was not investigated. We examined the association of ART and parental ages at childbirth for the development of eight epimutation-mediated imprinting disorders (epi-IDs). We enrolled 136 patients with epi-IDs and obtained general population ART data from the Japanese robust nationwide registry. We compared the proportion of ART-conceived livebirths and maternal childbearing ages between patients with epi-IDs and the general population. The proportion of ART-conceived livebirths in patients with epi-IDs was higher than that in mothers aged ≥ 30 years, the age group in which more than 90% of ART procedures performed. The maternal childbearing ages of patients with epi-IDs were widely distributed from 19 to 45 (median: 32) within the approximate 2.5th to 97.5th percentiles of maternal childbearing ages of the general population. In addition, we compared the proportion of ART-conceived livebirths and parental ages at childbirth across patients with eight epi-IDs. We demonstrated that more than 90% of ART-conceived patients with epi-IDs were found in Silver-Russell syndrome (SRS) and Beckwith-Wiedemann syndrome (BWS) patients, and parental ages were almost consistent in patients with eight epi-IDs, except Prader-Willi syndrome. According to the prerequisite that most of the ART procedures in Japan are performed on mothers aged ≥ 30 years, ART can be a risk factor for the development of epi-IDs, particularly SRS and BWS, for mothers aged ≥ 30 years.

中文翻译：

---

辅助生殖技术是 30 岁以上母亲发生表观突变介导的印记障碍的一个可能风险因素。

印迹障碍（ID）患者通过辅助生殖技术（ART）受孕的活产比例高于一般人群。这是否是由于 ART 或高龄父母的混杂影响尚未调查。我们检查了 ART 与生育时父母年龄之间的关联，以发现八种表观突变介导的印记障碍 (epi-ID)。我们招募了 136 名具有 Epi-ID 的患者，并从日本强大的全国登记处获得了一般人群 ART 数据。我们比较了 epi-ID 患者和一般人群之间 ART 受孕的活产率和孕产妇生育年龄的比例。Epi-IDs患者ART受孕的活产比例高于≥30岁的母亲，执行 90% 以上的 ART 手术的年龄组。Epi-IDs 患者的母体生育年龄广泛分布在 19 至 45 岁（中位数：32）之间，在一般人群母体生育年龄的大约 2.5% 至 97.5% 之间。此外，我们还比较了 8 个 epi-ID 患者的 ART 受孕活产比例和分娩时父母年龄。我们证明，超过 90% 的 ART 受孕的 Epi-ID 患者出现在 Silver-Russell 综合征 (SRS) 和 Beckwith-Wiedemann 综合征 (BWS) 患者中，并且在有 8 个 Epi-ID 的患者中，父母年龄几乎一致，除了普拉德威利综合征。根据日本大部分 ART 手术是在 30 岁以上的母亲身上进行的先决条件，ART 可能是发生 Epi-IDs 的危险因素，