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The Anti-Inflammatory Effect of Pistacia Lentiscus in a Rat Model of Colitis.
Journal of Inflammation Research ( IF 4.2 ) Pub Date : 2020-07-22 , DOI: 10.2147/jir.s259035 Maryam Ostovan 1 , Seyyed Mohammad Bagher Fazljou 1 , Hajar Khazraei 2 , Mostafa Araj Khodaei 1, 3 , Mohammadli Torbati 4
Journal of Inflammation Research ( IF 4.2 ) Pub Date : 2020-07-22 , DOI: 10.2147/jir.s259035 Maryam Ostovan 1 , Seyyed Mohammad Bagher Fazljou 1 , Hajar Khazraei 2 , Mostafa Araj Khodaei 1, 3 , Mohammadli Torbati 4
Affiliation
Introduction: The mastic tree (Pistacia lentiscus), belonging to the Anacardiaceae family, has anti-inflammatory and antioxidant properties. This study aims to assay the anti-inflammatory effects of mastic in rats with colitis.
Methods: Forty-eight male Sprague-Dawley rats were randomly divided into six groups of control, colitis without treatment, colitis with mastic (400 mg/kg/daily) administered orally or intra-rectally, colitis with prednisolone (5 mg/kg of body weight), and colitis with sesame oil for seven successive days. Treatment effects were evaluated by determining cytokines (TNFα, IL6) and myeloperoxidase (MPO) activity, macroscopic scores, and histopathological parameters. The results of each group are compared with colitis without treatment group.
Results: After administering sesame oil, the MPO level was reduced significantly compared to colitis without the treatment group (P=0.025). The mastic oil (400 mg/kg orally) administration was effective in reducing colitis severity through the reduction in the total colitis index (p=0.046) after 7 days. The Intra-rectal administration of mastic decreased TNF-α significantly, similar to prednisolone and control groups compared to the colitis without treatment group (p=0.024). The IL-6 did not change in the mastic and sesame oil groups.
Conclusion: According to our results, mastic and sesame oil have anti-inflammatory properties, suggesting that they could be used as natural sources to lessen the ulcerative colitis inflammation.
Keywords: mastic, colitis, inflammation, rats, sesame
中文翻译：
Pistacia Lentiscus 在大鼠结肠炎模型中的抗炎作用。
简介：乳香树（Pistacia lentiscus）属于漆树科，具有抗炎和抗氧化特性。本研究旨在测定乳香对结肠炎大鼠的抗炎作用。
方法：将 48 只雄性 Sprague-Dawley 大鼠随机分为 6 组对照组，结肠炎不治疗，结肠炎联合乳香（400 mg/kg/day）口服或直肠内给药，结肠炎联合泼尼松龙（5 mg/kg体重）和芝麻油结肠炎连续 7 天。通过确定细胞因子（TNFα、IL6）和髓过氧化物酶（MPO）活性、宏观评分和组织病理学参数来评估治疗效果。将各组的结果与未治疗组的结肠炎进行比较。
结果：给予芝麻油后，与未治疗组的结肠炎相比，MPO水平显着降低（P = 0.025）。乳香油（400 mg/kg 口服）给药在 7 天后通过降低总结肠炎指数（p=0.046）有效降低结肠炎严重程度。与未治疗的结肠炎组相比，乳香的直肠内给药显着降低了 TNF-α，类似于泼尼松龙和对照组（p = 0.024）。IL-6 在乳香油和芝麻油组中没有变化。
结论：根据我们的研究结果，乳香油和芝麻油具有抗炎特性，表明它们可以用作减轻溃疡性结肠炎炎症的天然来源。
关键词：乳香，结肠炎，炎症，大鼠，芝麻
更新日期：2020-07-22
Methods: Forty-eight male Sprague-Dawley rats were randomly divided into six groups of control, colitis without treatment, colitis with mastic (400 mg/kg/daily) administered orally or intra-rectally, colitis with prednisolone (5 mg/kg of body weight), and colitis with sesame oil for seven successive days. Treatment effects were evaluated by determining cytokines (TNFα, IL6) and myeloperoxidase (MPO) activity, macroscopic scores, and histopathological parameters. The results of each group are compared with colitis without treatment group.
Results: After administering sesame oil, the MPO level was reduced significantly compared to colitis without the treatment group (P=0.025). The mastic oil (400 mg/kg orally) administration was effective in reducing colitis severity through the reduction in the total colitis index (p=0.046) after 7 days. The Intra-rectal administration of mastic decreased TNF-α significantly, similar to prednisolone and control groups compared to the colitis without treatment group (p=0.024). The IL-6 did not change in the mastic and sesame oil groups.
Conclusion: According to our results, mastic and sesame oil have anti-inflammatory properties, suggesting that they could be used as natural sources to lessen the ulcerative colitis inflammation.
Keywords: mastic, colitis, inflammation, rats, sesame
中文翻译：
Pistacia Lentiscus 在大鼠结肠炎模型中的抗炎作用。
简介：乳香树（Pistacia lentiscus）属于漆树科，具有抗炎和抗氧化特性。本研究旨在测定乳香对结肠炎大鼠的抗炎作用。
方法：将 48 只雄性 Sprague-Dawley 大鼠随机分为 6 组对照组，结肠炎不治疗，结肠炎联合乳香（400 mg/kg/day）口服或直肠内给药，结肠炎联合泼尼松龙（5 mg/kg体重）和芝麻油结肠炎连续 7 天。通过确定细胞因子（TNFα、IL6）和髓过氧化物酶（MPO）活性、宏观评分和组织病理学参数来评估治疗效果。将各组的结果与未治疗组的结肠炎进行比较。
结果：给予芝麻油后，与未治疗组的结肠炎相比，MPO水平显着降低（P = 0.025）。乳香油（400 mg/kg 口服）给药在 7 天后通过降低总结肠炎指数（p=0.046）有效降低结肠炎严重程度。与未治疗的结肠炎组相比，乳香的直肠内给药显着降低了 TNF-α，类似于泼尼松龙和对照组（p = 0.024）。IL-6 在乳香油和芝麻油组中没有变化。
结论：根据我们的研究结果，乳香油和芝麻油具有抗炎特性，表明它们可以用作减轻溃疡性结肠炎炎症的天然来源。
关键词：乳香，结肠炎，炎症，大鼠，芝麻
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