Detection of magnetic field effects by confocal microscopy,Chemical Science

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Detection of magnetic field effects by confocal microscopy
Chemical Science ( IF 7.6 ) Pub Date : 2020-07-22 , DOI: 10.1039/d0sc01986k
Victoire Déjean ₁ , Marcin Konowalczyk _{1,

2} , Jamie Gravell ₁ , Matthew J Golesworthy ₁ , Catlin Gunn ₁ , Nils Pompe ₁ , Olivia Foster Vander Elst ₁ , Ke-Jie Tan ₃ , Mark Oxborrow ₃ , Dirk G A L Aarts ₂ , Stuart R Mackenzie ₂ , Christiane R Timmel _{1,

4}

Affiliation

Certain pairs of paramagnetic species generated under conservation of total spin angular momentum are known to undergo magnetosensitive processes. Two prominent examples of systems exhibiting these so-called magnetic field effects (MFEs) are photogenerated radical pairs created from either singlet or triplet molecular precursors, and pairs of triplet states generated by singlet fission. Here, we showcase confocal microscopy as a powerful technique for the investigation of such phenomena. We first characterise the instrument by studying the field-sensitive chemistry of two systems in solution: radical pairs formed in a cryptochrome protein and the flavin mononucleotide/hen egg-white lysozyme model system. We then extend these studies to single crystals. Firstly, we report temporally and spatially resolved MFEs in flavin-doped lysozyme single crystals. Anisotropic magnetic field effects are then reported in tetracene single crystals. Finally, we discuss the future applications of confocal microscopy for the study of magnetosensitive processes with a particular focus on the cryptochrome-based chemical compass believed to lie at the heart of animal magnetoreception.

中文翻译：

通过共聚焦显微镜检测磁场效应

已知在总自旋角动量守恒下产生的某些顺磁性物质对会经历磁敏过程。表现出这些所谓磁场效应 (MFE) 的系统的两个突出例子是由单线态或三线态分子前体产生的光生自由基对，以及由单线态裂变产生的三线态对。在这里，我们展示了共聚焦显微镜作为研究此类现象的强大技术。我们首先通过研究溶液中两个系统的场敏感化学来表征仪器：在隐花色素蛋白中形成的自由基对和黄素单核苷酸/鸡蛋清溶菌酶模型系统。然后我们将这些研究扩展到单晶。首先，我们报告了黄素掺杂的溶菌酶单晶中的时间和空间分辨的 MFE。然后在并四苯单晶中报告了各向异性磁场效应。最后，我们讨论了共聚焦显微镜在磁敏过程研究中的未来应用，特别关注基于隐花色素的化学罗盘，被认为是动物磁感受的核心。

更新日期：2020-08-05

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