Natural Product Communications ( IF 1.5 ) Pub Date : 2020-07-21 , DOI: 10.1177/1934578x20934933 Jingxin Chen 1 , Lin Ni 1, 2 , Yao Zhang 1 , Yingsa Zhu 3 , Wei Huang 2 , Shuangquan Zou 2
A new ellagic acid derivative 3,3′-di-O-methylellagic acid 4′-α-l-arabinopyranoside (1), with 9 known compounds identified as 3,3′-di-O-methylellagic acid (2), 3,3′-di-O-methylellagic acid 4′-α-d-arabinofuranoside (3), 3,3′-di-O-methylellagic acid 4′-β-d-glucopyranoside (4), 3,3′-di-O-methylellagic acid 4′-β-d-xylopyranoglucoside (5), 3,3′,4-tri-O-methylellagic acid 4′-β-d-glucopyranoside (6), tormentic acid (7), ursolic acid (8), euscaphic acid (9), and betulinic acid (10), was isolated from the twigs of Euscaphis konishii Hayata. Compounds 1, 3, and 5 to 7 were isolated from this plant for the first time, and compounds 1 and 5 were obtained from the plant genus for the first time. The structure of the new compound was confirmed by HRESIMS, NMR, and compared with data from the literature . The cytotoxicities of 10 isolated compounds were tested, with compounds 1 to 6 showing moderately inhibited activity against the Human Hepatocarcinoma cell line (HepG2 cells) with an IC50 value ranging from 69.7 to 181.8 μM.
中文翻译:
细叶Euscaphis konishii Hayata细枝中的化学成分及其活性
一种新的鞣花酸衍生物的3,3'-二- ö -methylellagic酸4 ' - α-升-arabinopyranoside(1)中,用9种已知化合物鉴定为3,3'-二- Ö -methylellagic酸(2),3 ,3'-二ö -methylellagic酸4'-α- d -arabinofuranoside(3),3,3'-二- ö -methylellagic酸4' - β- d吡喃葡萄糖苷(4),3,3'-二ø -methylellagic酸4 ' - β- d -xylopyranoglucoside(5),3,3',4-三ö -methylellagic酸4'-β-从小额叶草(Euscaphis konishii Hayata)的小枝中分离出d-吡喃葡萄糖苷(6),草酸(7),熊果酸(8),大黄酸(9)和桦木酸(10)。化合物1,3,及5至7,从该植物中首次分离得到,和化合物1和5从植物属首次得到。通过HRESIMS,NMR证实了新化合物的结构,并与文献数据进行了比较。测试了10种分离出的化合物的细胞毒性,其中化合物1图6至6显示出对人肝癌细胞系(HepG2细胞)的中等抑制活性,IC 50值为69.7至181.8μM。