The World Health Organization declared the severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 virus outbreak as a pandemic on May 27, 2020. Since then, more than 5 488 825 cases across the world have been recorded at the time of revising this article. Governments around the world have imposed serious containment measures, meanwhile, the healthcare system is overburdened due to large increases in COVID-19 cases. However, no specific anti-SARS-CoV-2 virus drugs or vaccines have yet been shown to be effective to fight this causative virus of acute infectious pneumonia. The current review was conducted to look for potential natural and synthesized drugs for the treatment of COVID-19 patients. Previously published data in journals, textbooks, periodicals, websites, and sources, including data about the treatment of human coronavirus with natural and synthesized drugs, were taken from the online bibliographical databases. The results showed that syndic drugs approved for other human diseases have been used to improve the symptoms of patients infected with SARS-CoV-2. Several clinical trials across the world evidenced beneficial effects of natural and synthesized drugs in the treatment of SARS-CoV-2 infections. On the other hand, many studies have provided a deep understanding of the therapeutic effects of conventional and traditional medicine in identifying naturally occurring drugs effective against the SARS-CoV-2 virus. Both natural and synthesized drugs should come together to fight the SARS-CoV-2 virus and other potential emerging dangerous viral diseases since they have shown promising findings in clinical trials conducted with COVID-19 patients.

世界卫生组织于2020年5月27日宣布严重急性呼吸系统综合症（SARS）-冠状病毒（CoV）-2病毒爆发为大流行。自那时以来，截至2008年，全世界已记录了5 488 825例病例修改本文。全世界的政府都采取了严格的收容措施，与此同时，由于COVID-19病例的大量增加，医疗体系负担沉重。然而，尚无特异性抗SARS-CoV-2病毒药物或疫苗可有效对抗这种急性传染性肺炎病原性病毒。进行当前审查以寻找用于治疗COVID-19患者的潜在天然和合成药物。以前在期刊，教科书，期刊，网站和资源中发布的数据，包括有关使用天然药物和合成药物治疗人冠状病毒的数据，均来自在线书目数据库。结果表明，批准用于其他人类疾病的辛迪加药物已用于改善感染SARS-CoV-2的患者的症状。全世界的一些临床试验证明了天然药物和合成药物在治疗SARS-CoV-2感染中的有益作用。另一方面，许多研究对常规和传统药物在鉴定对SARS-CoV-2病毒有效的天然药物中的治疗作用提供了深刻的理解。