Abstract

Consumption of walnuts is beneficial for cardiovascular health. To study walnut effects on proteins involved in vascular tone regulation, control and fructose-fed rats were subjected to walnut diet for 6 weeks. In contrast with increased energy intake and body mass gain, aortic protein level of L-type calcium channel alpha subunit was decreased and the level of SUR2B subunit of ATP-sensitive K + channel was increased in healthy rats subjected to walnuts, together with improved Akt phosphorylation. Upon the walnut diet in rats subjected to fructose overload, the rise in energy intake and body mass gain, was followed by an increase in blood insulin. Although SUR2B level was elevated, the level of sodium-calcium exchanger NCX1 and inducible nitric oxide synthase were reduced and increased, respectively. In summary, walnut consumption was accompanied with moderate beneficial vascular effect in healthy rats, while an effect of walnut in rats with metabolic disturbances was rather controversial.

摘要

食用核桃对心血管健康有益。为了研究核桃对参与血管张力调节的蛋白质的影响，对照和果糖喂养的大鼠接受了 6 周的核桃饮食。与能量摄入增加和体重增加相反，核桃的健康大鼠 L 型钙通道 α 亚基的主动脉蛋白水平降低，ATP 敏感 K + 通道的 SUR2B 亚基水平升高，同时 Akt 提高磷酸化。在果糖超载的大鼠中，核桃饮食后，能量摄入增加和体重增加，随后血胰岛素增加。虽然 SUR2B 水平升高，但钠钙交换剂 NCX1 和诱导型一氧化氮合酶的水平分别降低和增加。总之，