ABSTRACT Cell division cycle and apoptosis regulator 1 (CCAR1) is a deleted in breast cancer domain containing protein and their molecular roles in the animal system are well characterized. So far study on CCAR1 protein has not available in the plant system. The domain-based phylogenetic study clearly indicates that the CCAR1 protein has widely distributed throughout the plant kingdom. Intron-less CCAR1 gene encoded protein comprises five conserved domain and huge intrinsic disorder. Functional annotation of cis-regulatory elements (CREs) reveales that a wide range of potential transcription factor binding sites (TFBSs) are present in CCAR1 gene promoter. Besides that potential miRNA targets those control post-transcriptional regulations are also identified in the present study. Furthermore, gene ontogeny (GO) analysis revealed that CCAR1 have dynamic role in a wide number of cellular and metabolic processes. In this study, we first report the regulation, functional and structural property of CCAR1 transcript and protein which will help to assist crop improvement by manipulating CCAR1.

中文翻译：

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Morus notabilis 中细胞分裂周期和细胞凋亡调节因子 1 (CCAR1) 蛋白的新方面：一种计算机方法

摘要 细胞分裂周期和细胞凋亡调节因子 1 (CCAR1) 是一种缺失的乳腺癌结构域蛋白，它们在动物系统中的分子作用已得到充分表征。迄今为止，在植物系统中还没有关于CCAR1蛋白的研究。基于域的系统发育研究清楚地表明 CCAR1 蛋白广泛分布于整个植物界。无内含子 CCAR1 基因编码的蛋白质包括五个保守结构域和巨大的内在障碍。顺式调控元件 (CRE) 的功能注释表明 CCAR1 基因启动子中存在广泛的潜在转录因子结合位点 (TFBS)。除了潜在的 miRNA 目标之外，本研究还确定了那些控制转录后调控。此外，基因个体发育 (GO) 分析显示 CCAR1 在许多细胞和代谢过程中具有动态作用。在这项研究中，我们首先报告了 CCAR1 转录本和蛋白质的调控、功能和结构特性，这将有助于通过操纵 CCAR1 来帮助作物改良。