ABSTRACT Renal sympathetic denervation (RSD) is a new method for the treatment of resistant hypertension (RH). However, few studies have focused on the effects of RSD on blood flow and the interaction between temperature field and flow field. In this paper, firstly, we designed a numerical simulation of electromagnetic field, flow field and temperature field coupling by finite element method. Secondly, numerical simulation results were verified by particle image velocimetry (PIV) and vitro experiment. From the simulation results, when the flow velocity increases to 0.05 m/s, the turbulence near the electrode disappeared and flow state became uniform laminar flow. With the increases of flow velocity (0 m/s to 0.1 m/s), temperature rise of the renal artery, the electrode tip and blood decreased from 13°C, 24°C and 5.4°C to 9.3°C, 9.7°C and 0.2°C, respectively. From PIV experiment and vitro experiment results, when the flow rate increases to 0.5 L/min, it appeared similar phenomenon with the velocity of 0.05 m/s in simulation. With the increases of flow rate (0 L/min to 0.8 L/min), temperature rise of three points decreased from 11.2°C, 20.5°C and 3.6°C to 7.8°C, 8.5°C, and 0.4°C, respectively. When the blood flow rate exceeds 0.5 L/min, there is no large velocity gradient and reflux area in the flow field, so there will be no hemolysis and thrombosis. Therefore, the temperature field has less influence on the flow field. With the increase of flow rate, the temperature at all three points decreases. Therefore, the flow field has an effect on the temperature field. But the central temperature of renal artery can still reach the treatment target in which temperature rises to be more than 6°C. Therefore, this study preliminarily verified the safety and effectiveness of RSD.

中文翻译：

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肾交感神经射频消融流场研究：数值模拟和PIV实验

【摘要】：肾交感神经去神经支配术(RSD)是一种治疗难治性高血压(RH)的新方法。然而，很少有研究关注 RSD 对血流的影响以及温度场与流场之间的相互作用。在本文中，我们首先采用有限元方法设计了电磁场、流场和温度场耦合的数值模拟。其次，通过粒子图像测速（PIV）和体外实验验证了数值模拟结果。从模拟结果来看，当流速增加到0.05 m/s时，电极附近的湍流消失，流动状态变为均匀层流。随着流速的增加（0 m/s 到 0.1 m/s），肾动脉、电极尖端和血液的温度从 13°C、24°C 和 5.4°C 下降到 9.3°C、9.7° C 和 0.2°C，分别。从PIV实验和体外实验结果来看，当流速增加到0.5 L/min时，出现类似的现象，模拟流速为0.05 m/s。随着流速的增加（0 L/min 到 0.8 L/min），三个点的温升从 11.2°C、20.5°C 和 3.6°C 下降到 7.8°C、8.5°C 和 0.4°C，分别。当血流量超过0.5L/min时，流场内没有大的速度梯度和回流区，因此不会发生溶血和血栓形成。因此，温度场对流场的影响较小。随着流量的增加，三点温度均下降。因此，流场对温度场有影响。但肾动脉中心温度升高6℃以上仍可达到治疗目标。