Abstract

In present study, multi-target and multi-pathway mechanisms of Jasminum lanceolarium Roxb (JL) on primary dysmenorrhea (PDM) treatment were predicted by the approach of network pharmacology and molecular docking, leading to the obtaining of 22 predicted targets for 69 compounds in JL. The Compound-Target analysis displayed intimate association among targets and compounds. Meanwhile, the Compound-Target-Target revealed PTGS2, OPRD1 and NOS3 were the key targets with intensive interaction. The Compound-Target-Pathway network indicated these pathways were closely related to hormone regulation, central analgesia, spasmolysis and inflammation. The anti-inflammation pathways might be the key mechanism of JL for the treatment of PDM based on KEGG pathway enrichment analysis and pharmacological experiment, and 10-hydroxyoleoside dimethyl ester might be a promising leading compound due to its good molecular docking scores and previous experimental evaluation.

摘要

本研究通过网络药理学和分子对接的方法预测了Jasminum lanceolarium Roxb（JL）治疗原发性痛经（PDM）的多靶点、多途径机制，获得了69种化合物的22个预测靶点。 JL。化合物-目标分析显示目标和化合物之间的密切关联。同时，Compound-Target-Target揭示了PTGS2、OPRD1和NOS3是相互作用强烈的关键靶点。Compound-Target-Pathway 网络表明这些通路与激素调节、中枢镇痛、解痉和炎症密切相关。基于KEGG通路富集分析和药理实验，抗炎通路可能是JL治疗PDM的关键机制，