ABSTRACT

Introduction

Platelet-rich plasma (PRP) is able to modulate the joint environment by reducing the inflammatory distress and promoting tissue anabolism. Therefore, it has gained increasing popularity among clinicians in the treatment of osteoarthritis (OA), and it is currently proposed beside consolidated options such as viscosupplementation.

Areas covered

A systematic review of all available meta-analyses evaluating intra-articular PRP injections in patients affected by knee OA was performed, to understand how this biologic treatment approach compares to the traditional injective therapies available in clinical practice. Moreover, a novel coding system and ‘minimum reporting requirements’ are proposed to improve future research in this field and promote a better understanding of the mechanisms of action and indications.

Expert opinion

The main limitation in the current literature is the extreme variability of PRP products used, with often paucity or even lack of data on the biologic features of PRP, which should not be considered as a simple substance, but rather a ‘procedure’ requiring accurate reporting of the characteristics of the product but also all preparation and application modalities. This approach will aid in matching the optimal PRP product to specific patient factors, leading to improved outcomes and the elucidation of the cost-effectiveness of this treatment.

中文翻译：

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用于治疗膝骨关节炎的富含血小板的血浆：关于新型分类和编码系统的专家意见和建议。

摘要

介绍

富含血小板的血浆 (PRP) 能够通过减少炎症窘迫和促进组织合成代谢来调节关节环境。因此，它在治疗骨关节炎 (OA) 的临床医生中越来越受欢迎，并且目前建议将其与诸如粘性补充剂等综合选项一起使用。

覆盖区域

对评估膝关节 OA 患者关节内 PRP 注射的所有可用荟萃分析进行了系统评价，以了解这种生物治疗方法与临床实践中可用的传统注射疗法的比较。此外，还提出了一种新的编码系统和“最低报告要求”，以改进该领域的未来研究，并促进对作用机制和适应症的更好理解。

专家意见

当前文献中的主要限制是所用 PRP 产品的极端可变性，通常缺乏甚至缺乏关于 PRP 生物学特征的数据，不应将其视为单一物质，而是需要准确报告的“程序”产品的特性以及所有的制备和应用方式。这种方法将有助于将最佳 PRP 产品与特定的患者因素相匹配，从而改善结果并阐明这种治疗的成本效益。