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Tc17 biology and function: Novel concepts.
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-07-22 , DOI: 10.1002/eji.202048627 Christina Lückel 1 , Felix S R Picard 2 , Magdalena Huber 2
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-07-22 , DOI: 10.1002/eji.202048627 Christina Lückel 1 , Felix S R Picard 2 , Magdalena Huber 2
Affiliation
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Research over the past years has provided increasing understanding about IL‐17‐producing CD8+ T cells termed Tc17 or IL‐17+CD8+ T cells, their distribution and role in a range of diverse immune processes. These comprise resistance to pathogens and tissue homeostasis, but also contribution to autoimmunity and cancer, as well as involvement in gut inflammation, lung diseases and graft‐versus‐host‐disease. Tc17 cells are regulated by unique differentiation mechanisms distinguishing them from other IL‐17‐producing T cells, including Th17, mucosal‐associated invariant T cells, and γδ17 T cells, thus ensuring their specific function in immune responses. Here, we review recent advances in understanding Tc17 cell differentiation and function, and highlight experimental evidence from human studies on patients suffering from organ‐specific autoimmunity including psoriasis, spondyloarthritis and MS as well as from ulcerative colitis and gastrointestinal tract‐associated cancers. We also discuss mouse models analyzing Tc17 characteristics and indicate mechanisms of cross‐talk between Tc17 cells and immune or nonimmune cells, enabling their effector function in both protective as well as pathologic immune responses.
中文翻译：
Tc17生物学和功能：新概念。
过去几年的研究使人们对被称为Tc17或IL-17 + CD8 +的产生IL-17的CD8 + T细胞有了越来越多的了解。T细胞及其在各种免疫过程中的分布和作用。这些包括对病原体和组织稳态的抵抗力，还对自身免疫和癌症做出贡献，并参与肠道炎症，肺部疾病和移植物抗宿主病。Tc17细胞受独特的分化机制调控，使其与其他产生IL-17的T细胞（包括Th17，与粘膜相关的不变T细胞和γδ17T细胞）区分开，从而确保了它们在免疫应答中的特定功能。在这里，我们回顾了在了解Tc17细胞分化和功能方面的最新进展，并重点介绍了来自人类研究的实验证据，这些研究针对患有器官特异性自身免疫的患者，包括牛皮癣，脊椎关节炎和MS以及溃疡性结肠炎和胃肠道相关癌症。
更新日期：2020-09-03
中文翻译：
Tc17生物学和功能：新概念。
过去几年的研究使人们对被称为Tc17或IL-17 + CD8 +的产生IL-17的CD8 + T细胞有了越来越多的了解。T细胞及其在各种免疫过程中的分布和作用。这些包括对病原体和组织稳态的抵抗力，还对自身免疫和癌症做出贡献，并参与肠道炎症，肺部疾病和移植物抗宿主病。Tc17细胞受独特的分化机制调控，使其与其他产生IL-17的T细胞（包括Th17，与粘膜相关的不变T细胞和γδ17T细胞）区分开，从而确保了它们在免疫应答中的特定功能。在这里，我们回顾了在了解Tc17细胞分化和功能方面的最新进展，并重点介绍了来自人类研究的实验证据，这些研究针对患有器官特异性自身免疫的患者，包括牛皮癣，脊椎关节炎和MS以及溃疡性结肠炎和胃肠道相关癌症。
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