Right now the world is going through an unprecedented pandemic caused by a novel coronavirus. Recent papers pointed out the fatal outcome in most of the severe cases, in which a cytokine storm has been proven to be the cause of a systemic shock, acute respiratory syndrome, multiorgan failure and consequently death. Several explanations have been proposed trying to explain the pathophysiology of the cytokine storm, but viral proteins with a possible superantigen activity as a cause of immune dysregulation have not been addressed. If this hypothesis is proven, a different treatment approach might change the outcome in severe cases.

中文翻译：

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超抗原是严重 COVID-19 中细胞因子风暴和病毒性败血症的原因吗？观察和假设。

目前，世界正在经历一场由新型冠状病毒引起的前所未有的大流行。最近的论文指出了大多数严重病例的致命后果，其中细胞因子风暴已被证明是导致全身性休克、急性呼吸综合征、多器官衰竭并因此死亡的原因。已经提出了几种解释，试图解释细胞因子风暴的病理生理学，但具有可能超抗原活性的病毒蛋白作为免疫失调的原因尚未得到解决。如果这一假设得到证实，则不同的治疗方法可能会改变严重病例的结果。