Poly(Caprolactone)‐Poly( N ‐Isopropyl Acrylamide)‐Fe 3 O 4 Magnetic Nanofibrous Structure with Stimuli Responsive Drug Release,Macromolecular Materials and Engineering

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Poly(Caprolactone)‐Poly( N ‐Isopropyl Acrylamide)‐Fe 3 O 4 Magnetic Nanofibrous Structure with Stimuli Responsive Drug Release
Macromolecular Materials and Engineering ( IF 4.2 ) Pub Date : 2020-07-21 , DOI: 10.1002/mame.202000208
Sanaz Gholami ₁ , Sheyda Labbaf ₁ , Ahmad Kermanpur ₁ , Arezou Baharlou Houreh ₂ , Chaojie Luo ₃ , Mohan Edirisinghe ₃ , Mohammad‐Hossein Nasr Esfahani ₂

Affiliation

Poly(caprolactone; PCL)—poly(N‐isopropylacrylamie; PNIPAAm)—Fe3O4 fiber, that can be magnetically actuated, is reported. Here, a structure is engineered that can be utilized as a smart carrier for the release of chemotherapeutic drug via magneto‐thermal activation, with the aid of magnetic nanoparticles (MNPs). The magnetic measurement of the fibers revealed saturation magnetization values within the range of 1.2–2.2 emu g−1. The magnetic PCL‐PNIPAAm‐Fe3O4 scaffold shows a specific loss power value of 4.19 W g−1 at 20 wt% MNPs. A temperature increase of 40 °C led to a 600% swelling after only 3 h. Doxorubicin (DOX) as a model drug, demonstrates a controllable drug release profile. 39% ± 0.92 of the total drug loaded is released after 96 h at 37 °C, while 25% drug release in 3 h at 40 °C is detected. Cytotoxicity results show no significant difference in cell attachment efficiency between the MNP‐loaded fibers and control while the DOX‐loaded fibers effectively inhibited cell proliferation at 24 h matching the drug release profile. The noncytotoxic effect, coupled with the magneto‐thermal property and controlled drug release, renders excellent potential for these fibers to be used as a smart drug‐release agent for localized cancer therapy.

中文翻译：

具有刺激响应性药物释放的聚（己内酯）-聚（N-异丙基丙烯酰胺）-Fe 3 O 4 磁性纳米纤维结构

据报道，聚（己内酯；PCL）-聚（N-异丙基丙烯酰胺；PNIPAAm）-Fe3O4 纤维可以被磁致动。在这里，设计了一种结构，可用作智能载体，在磁性纳米粒子 (MNP) 的帮助下，通过磁热激活释放化疗药物。纤维的磁性测量显示饱和磁化强度值在 1.2–2.2 emu g-1 范围内。磁性 PCL-PNIPAAm-Fe3O4 支架在 20 wt% 的 MNP 下显示出 4.19 W g-1 的特定损耗功率值。仅 3 小时后，温度升高 40 °C 就会导致 600% 的溶胀。多柔比星 (DOX) 作为模型药物，表现出可控的药物释放曲线。在 37 °C 下 96 小时后释放了总载药量的 39% ± 0.92，而在 40 °C 下 3 小时内检测到 25% 的药物释放。细胞毒性结果表明，加载 MNP 的纤维和对照之间的细胞附着效率没有显着差异，而加载 DOX 的纤维在 24 小时内有效抑制细胞增殖，与药物释放曲线相匹配。非细胞毒性作用，加上磁热特性和受控药物释放，使这些纤维具有用作局部癌症治疗的智能药物释放剂的巨大潜力。

更新日期：2020-07-21

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