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Antioxidant and antiglycation activities of traditional plants and identification of bioactive compounds from extracts of Hordeum vulgare by LC-MS and GC-MS.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-07-22 , DOI: 10.1111/jfbc.13381 Awais Asif 1, 2 , Nadia Zeeshan 2 , Sajid Mehmood 3
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-07-22 , DOI: 10.1111/jfbc.13381 Awais Asif 1, 2 , Nadia Zeeshan 2 , Sajid Mehmood 3
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Glycation has been involved in Schiff base reaction lead to hyperglycemia at cellular level. The current study aimed to identify the bioactive compounds from selected folkloric plants for their antiglycation and antioxidant potential. Methanol extracts demonstrated the highest activities, therefore, it was further fractionated using n‐hexane, dichloromethane, ethyl acetate, and methanol solvents to isolate the nonpolar compounds from the Hordeum vulgare. Moreover, n‐hexane and dichloromethane fractions of H. vulgare demonstrated the best antioxidant (61.58% and 62.89%) and antiglycation activities (72.52% and 61.52%) at 2 mg/ml, respectively. Analytical techniques of LC–MS and GC–MS were employed for identification of bioactive compounds; Biochanin A in dichloromethane (DCM) and Vitamin E in n‐hexane fractions. There was a strong correlation between antioxidant and antiglycation activities (r = 0.97 and r = 0.96) of DCM & n‐hexane fractions of H. vulgare. Findings of this study established the role of Biochanin A and Vit E from H. vulgare as potent antiglycation agents.
中文翻译：
LC-MS和GC-MS鉴定传统植物的抗氧化和抗糖化活性，并从大麦提取物中鉴定出生物活性化合物。
糖基化已参与席夫碱反应，导致细胞水平的高血糖。当前的研究旨在鉴定民用植物中的生物活性化合物的抗糖化作用和抗氧化能力。甲醇提取物表现出最高的活性，因此，它是使用进一步分馏Ñ己烷，二氯甲烷，乙酸乙酯和甲醇的溶剂从非极性化合物隔离大麦。此外，Ñ的己烷和二氯甲烷馏份H.大麦分别在2 mg / ml时表现出最佳的抗氧化剂（61.58％和62.89％）和抗糖化活性（72.52％和61.52％）。LC-MS和GC-MS的分析技术用于鉴定生物活性化合物。鹰嘴豆芽素A在二氯甲烷（DCM）和维生素E在Ñ正己烷级分。有抗氧化剂和抗糖化活动（之间存在强相关- [R = 0.97和- [R DCM的= 0.96）＆Ñ的己烷馏分H.大麦。这项研究的结果建立鹰嘴豆芽素A和维生素E的从角色H.大麦作为有效的抗糖化剂。
更新日期：2020-09-14
中文翻译：
LC-MS和GC-MS鉴定传统植物的抗氧化和抗糖化活性，并从大麦提取物中鉴定出生物活性化合物。
糖基化已参与席夫碱反应，导致细胞水平的高血糖。当前的研究旨在鉴定民用植物中的生物活性化合物的抗糖化作用和抗氧化能力。甲醇提取物表现出最高的活性，因此，它是使用进一步分馏Ñ己烷，二氯甲烷，乙酸乙酯和甲醇的溶剂从非极性化合物隔离大麦。此外，Ñ的己烷和二氯甲烷馏份H.大麦分别在2 mg / ml时表现出最佳的抗氧化剂（61.58％和62.89％）和抗糖化活性（72.52％和61.52％）。LC-MS和GC-MS的分析技术用于鉴定生物活性化合物。鹰嘴豆芽素A在二氯甲烷（DCM）和维生素E在Ñ正己烷级分。有抗氧化剂和抗糖化活动（之间存在强相关- [R = 0.97和- [R DCM的= 0.96）＆Ñ的己烷馏分H.大麦。这项研究的结果建立鹰嘴豆芽素A和维生素E的从角色H.大麦作为有效的抗糖化剂。
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