Cranial cruciate ligament rupture (CCLR) is one of the leading causes of pelvic limb lameness in dogs. About 6% of Labrador Retrievers suffer from this orthopedic problem. The aim of this study was to determine the heritability of CCLR in this breed using SNP array genotyping data. DNA samples were collected from CCLR‐affected dogs (n = 190) and unaffected dogs over the age of 8 years (n = 143). All 333 dogs were genotyped directly or imputed up to approximately 710k SNPs on the Affymetrix Axiom CanineHD SNP array. Heritability of CCLR was calculated using multiple methodologies, including linear mixed models, Bayesian models and a model that incorporates LD. The covariates of sex and sterilization status were added to each analysis to assess their impact. Across the algorithms of these models, heritability ranged from 0.550 to 0.886, depending on covariate inclusion. The relatively high heritability for this disease indicates that a substantial genetic component contributes to CCLR in the Labrador Retriever.

中文翻译：

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拉布拉多犬颅十字韧带断裂的基于 SNP 的遗传性和遗传结构。

颅交叉韧带断裂（CCLR）是犬骨盆肢体跛行的主要原因之一。大约 6% 的拉布拉多猎犬患有这种骨科问题。本研究的目的是使用 SNP 阵列基因分型数据确定该品种 CCLR 的遗传力。从受 CCLR 影响的狗 ( n  = 190) 和 8 岁以上未受影响的狗 ( n = 143）。在 Affymetrix Axiom CanineHD SNP 阵列上直接对所有 333 只狗进行基因分型或估算多达约 710k 个 SNP。CCLR 的遗传力使用多种方法计算，包括线性混合模型、贝叶斯模型和包含 LD 的模型。性别和绝育状态的协变量被添加到每个分析中以评估它们的影响。在这些模型的算法中，遗传力的范围从 0.550 到 0.886，具体取决于协变量的包含情况。这种疾病相对较高的遗传率表明，拉布拉多猎犬的 CCLR 有很大的遗传成分。