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A Rotating Spiral Micromotor for Noninvasive Zygote Transfer
Advanced Science ( IF 14.3 ) Pub Date : 2020-07-21 , DOI: 10.1002/advs.202000843 Lukas Schwarz 1 , Dmitriy D Karnaushenko 1 , Franziska Hebenstreit 1 , Ronald Naumann 2 , Oliver G Schmidt 1, 3, 4 , Mariana Medina-Sánchez 1
Advanced Science ( IF 14.3 ) Pub Date : 2020-07-21 , DOI: 10.1002/advs.202000843 Lukas Schwarz 1 , Dmitriy D Karnaushenko 1 , Franziska Hebenstreit 1 , Ronald Naumann 2 , Oliver G Schmidt 1, 3, 4 , Mariana Medina-Sánchez 1
Affiliation
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Embryo transfer (ET) is a decisive step in the in vitro fertilization process. In most cases, the embryo is transferred to the uterus after several days of in vitro culture. Although studies have identified the beneficial effects of ET on proper embryo development in the earlier stages, this strategy is compromised by the necessity to transfer early embryos (zygotes) back to the fallopian tube instead of the uterus, which requires a more invasive, laparoscopic procedure, termed zygote intrafallopian transfer (ZIFT). Magnetic micromotors offer the possibility to mitigate such surgical interventions, as they have the potential to transport and deliver cellular cargo such as zygotes through the uterus and fallopian tube noninvasively, actuated by an externally applied rotating magnetic field. This study presents the capture, transport, and release of bovine and murine zygotes using two types of magnetic micropropellers, helix and spiral. Although helices represent an established micromotor architecture, spirals surpass them in terms of motion performance and with their ability to reliably capture and secure the cargo during both motion and transfer between different environments. Herein, this is demonstrated with murine oocytes/zygotes as the cargo; this is the first step toward the application of noninvasive, magnetic micromotor‐assisted ZIFT.
中文翻译：
用于无创受精卵转移的旋转螺旋微电机
胚胎移植（ET）是体外受精过程中的决定性步骤。在大多数情况下，胚胎在体外培养几天后被转移到子宫。尽管研究已经确定了 ET 对早期胚胎正常发育的有益影响，但这种策略因需要将早期胚胎（受精卵）转移回输卵管而不是子宫而受到损害，这需要更具侵入性的腹腔镜手术，称为合子输卵管内移植（ZIFT）。磁性微电机提供了减轻此类手术干预的可能性，因为它们有可能在外部施加的旋转磁场的驱动下，通过子宫和输卵管无创地运输和递送细胞货物，例如受精卵。本研究介绍了使用两种类型的磁性微螺旋桨（螺旋和螺线）捕获、运输和释放牛和鼠受精卵。尽管螺旋代表了一种已建立的微电机架构，但螺旋在运动性能方面以及在不同环境之间的运动和转移过程中可靠地捕获和固定货物的能力方面超越了它们。在此，用小鼠卵母细胞/受精卵作为货物证明了这一点；这是应用非侵入性磁性微电机辅助 ZIFT 的第一步。
更新日期：2020-09-23
中文翻译：
用于无创受精卵转移的旋转螺旋微电机
胚胎移植（ET）是体外受精过程中的决定性步骤。在大多数情况下，胚胎在体外培养几天后被转移到子宫。尽管研究已经确定了 ET 对早期胚胎正常发育的有益影响，但这种策略因需要将早期胚胎（受精卵）转移回输卵管而不是子宫而受到损害，这需要更具侵入性的腹腔镜手术，称为合子输卵管内移植（ZIFT）。磁性微电机提供了减轻此类手术干预的可能性，因为它们有可能在外部施加的旋转磁场的驱动下，通过子宫和输卵管无创地运输和递送细胞货物，例如受精卵。本研究介绍了使用两种类型的磁性微螺旋桨（螺旋和螺线）捕获、运输和释放牛和鼠受精卵。尽管螺旋代表了一种已建立的微电机架构，但螺旋在运动性能方面以及在不同环境之间的运动和转移过程中可靠地捕获和固定货物的能力方面超越了它们。在此，用小鼠卵母细胞/受精卵作为货物证明了这一点；这是应用非侵入性磁性微电机辅助 ZIFT 的第一步。
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