Protein-mineral interaction is known to regulate biomineral stability and morphology. We hypothesise that fluid phases produce highly dynamic protein-mineral complexes involved in physiology and pathology of biomineralisation. Here, we specifically focus on calciprotein particles, complexes of vertebrate mineral-binding proteins and calcium phosphate present in the systemic circulation and abundant in extracellular fluids - hence the designation of the ensuing protein-mineral complexes as “mud in the blood”. These complexes exist amongst other extracellular particles that we collectively refer to as “the particle zoo”.

中文翻译：

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血液中的泥浆：蛋白质-矿物质复合物和细胞外囊泡在生物矿化和钙化中的作用。

已知蛋白质-矿物质相互作用可调节生物矿物质的稳定性和形态。我们假设流体相产生高度动态的蛋白质 - 矿物质复合物，涉及生物矿化的生理学和病理学。在这里，我们特别关注钙蛋白颗粒、脊椎动物矿物质结合蛋白和磷酸钙的复合物，这些复合物存在于体循环中并且在细胞外液中含量丰富——因此，随后的蛋白质-矿物质复合物被称为“血液中的泥浆”。这些复合物存在于我们统称为“粒子动物园”的其他细胞外粒子中。