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Association between male infertility and male-specific malignancies: systematic review and meta-analysis of population-based retrospective cohort studies
Fertility and Sterility ( IF 6.6 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.fertnstert.2020.04.042
Francesco Del Giudice 1 , Alex M Kasman 2 , Ettore De Berardinis 3 , Gian Maria Busetto 3 , Federico Belladelli 4 , Michael L Eisenberg 5
Affiliation  

OBJECTIVE To investigate the current evidence that correlates impaired male fertility with the risk of developing male-related malignancies. DESIGN Systematic review and meta-analysis of population-based retrospective cohort studies. SETTING Not applicable. PATIENT(S) Men diagnosed with impaired fertility status and subsequently observed to determine incidence risk in developing testicular cancer (TCa) or prostate cancer (PCa). INTERVENTION(S) Not applicable. MAIN OUTCOME MEASURE(S) Pooled risk ratio (RR) differences among male factor infertility subjects compared with a fertile control population, and meta-regression analysis according to age at baseline, mean follow-up, range of study time, and year of publication. RESULT(S) Six studies met the inclusion criteria and were critically examined. Four studies examined male infertility and TCa (n = 161,634; 174 TCa cases), and four examined infertility in relation to PCa (n = 183,950 men; 377 PCa cases) from 1963 to 2014. The pooled RR was 2.033 (95% confidence interval [CI], 1.66-2.48); heterogeneity: Q = 3.04 (degree of freedom [df] = 3); I2 = 1.55% for TCa and 1.68 (95% CI, 1.17-2.4); Q = 23.3(df = 3); I2 = 87.1% for PCa. CONCLUSION(S) Male infertility was associated with a subsequent risk of both TCa and PCa. Although the clinical significance of these findings remains uncertain, future studies should evaluate the underlying mechanisms to determine whether testis and prostate screening practices should be altered in men with male infertility. CLINICAL TRIAL REGISTRATION NUMBER PROSPERO 167277.

中文翻译:

男性不育与男性特异性恶性肿瘤之间的关联:基于人群的回顾性队列研究的系统评价和荟萃分析

目的 调查将男性生育能力受损与发展为男性相关恶性肿瘤的风险相关联的当前证据。设计 基于人群的回顾性队列研究的系统评价和荟萃分析。设置 不适用。患者 男性被诊断出生育能力受损,随后观察以确定发生睾丸癌 (TCa) 或前列腺癌 (PCa) 的发病风险。干预(S) 不适用。主要结果测量(S) 男性因素不育受试者与生育对照人群相比的汇总风险比(RR)差异,以及根据基线年龄、平均随访、研究时间范围和出版年份的元回归分析. 结果 六项研究符合纳入标准并经过严格审查。从 1963 年到 2014 年,四项研究检查了男性不育和 TCa(n = 161,634;174 例 TCa 病例),四项研究检查了与 PCa 相关的不孕症(n = 183,950 例;377 PCa 病例)。汇总的 RR 为 2.033(95% 置信区间) [CI],1.66-2.48);异质性:Q = 3.04(自由度 [df] = 3);I2 = TCa 的 1.55% 和 1.68(95% CI,1.17-2.4);Q = 23.3(df = 3); 对于 PCa,I2 = 87.1%。结论 (S) 男性不育与 TCa 和 PCa 的后续风险相关。尽管这些发现的临床意义仍然不确定,但未来的研究应该评估潜在的机制,以确定是否应该改变男性不育男性的睾丸和前列腺筛查实践。临床试验注册号 PROSPERO 167277。377 PCa 病例)从 1963 年到 2014 年。汇总 RR 为 2.033(95% 置信区间 [CI],1.66-2.48);异质性:Q = 3.04(自由度 [df] = 3);I2 = TCa 的 1.55% 和 1.68(95% CI,1.17-2.4);Q = 23.3(df = 3); 对于 PCa,I2 = 87.1%。结论 (S) 男性不育与 TCa 和 PCa 的后续风险相关。尽管这些发现的临床意义仍然不确定,但未来的研究应该评估潜在的机制,以确定是否应该改变男性不育男性的睾丸和前列腺筛查实践。临床试验注册号 PROSPERO 167277。377 PCa 病例)从 1963 年到 2014 年。汇总 RR 为 2.033(95% 置信区间 [CI],1.66-2.48);异质性:Q = 3.04(自由度 [df] = 3);I2 = TCa 的 1.55% 和 1.68(95% CI,1.17-2.4);Q = 23.3(df = 3); 对于 PCa,I2 = 87.1%。结论 (S) 男性不育与 TCa 和 PCa 的后续风险相关。尽管这些发现的临床意义仍然不确定,但未来的研究应该评估潜在的机制,以确定是否应该改变男性不育男性的睾丸和前列腺筛查实践。临床试验注册号 PROSPERO 167277。结论 (S) 男性不育与 TCa 和 PCa 的后续风险相关。尽管这些发现的临床意义仍然不确定,但未来的研究应该评估潜在的机制,以确定是否应该改变男性不育男性的睾丸和前列腺筛查实践。临床试验注册号 PROSPERO 167277。结论 (S) 男性不育与 TCa 和 PCa 的后续风险相关。尽管这些发现的临床意义仍然不确定,但未来的研究应该评估潜在的机制,以确定是否应该改变男性不育男性的睾丸和前列腺筛查实践。临床试验注册号 PROSPERO 167277。
更新日期:2020-11-01
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