Species A rotaviruses are a major cause of acute gastroenteritis in infants and young children worldwide. Reassortment is a common phenomenon due to the segmented nature of the rotavirus genome. The complete coding sequences of a species A rotavirus strain isolated from the feces of a child with acute gastroenteritis in Japan in 2018 were determined using an unbiased viral metagenomics approach. The genetic analysis revealed that the rotavirus strain had an unusual genomic constellation (G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E2-H1), suggesting reassortment of a genotype 1 with a genotype 2 rotavirus, from which the NSP4-encoding gene was acquired.

种类轮状病毒是全世界婴幼儿急性胃肠炎的主要原因。由于轮状病毒基因组的分段性质，重配是常见现象。使用无偏病毒宏基因组学方法确定了2018年从日本一名患有急性胃肠炎的儿童粪便中分离出的A型轮状病毒株的完整编码序列。遗传分析显示，轮状病毒菌株具有异常的基因组构型（G1-P [8] -I1-R1-C1-M1-A1-N1-T1-E2-H1），表明基因型1与基因型2的重配。轮状病毒，从中获得了编码NSP4的基因。