Abstract

Spirocyclic compounds fascinate the synthetic chemists due to their privileged ring system and efficacy in drug discovery. Many natural compounds comprise spirocyclic moiety in their skeleton and are effective in pharmaceutical industry. Over the years, many synthetic methodologies have been established for the construction of spirocyclic compounds. In this review, recent synthetic approaches to accessing various spirocompounds comprising six-membered carbocycles/heterocycles have been summarized.

Graphic abstract

中文翻译：

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合成包含六元碳环/杂环系统的螺环化合物的最新合成策略。

 抽象的

螺环化合物因其独特的环系统和在药物发现中的功效而令合成化学家着迷。许多天然化合物在其骨架中包含螺环部分并且在制药工业中有效。多年来，已经建立了许多用于构建螺环化合物的合成方法。在这篇综述中，总结了最近获得包含六元碳环/杂环的各种螺化合物的合成方法。

 图文摘要