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Mycobacterium tuberculosis var. tuberculosis infection in two captive black capuchins (Sapajus nigritus) in Southern Brazil
Brazilian Journal of Microbiology ( IF 2.1 ) Pub Date : 2020-07-22 , DOI: 10.1007/s42770-020-00339-5
Luiza Presser Ehlers 1 , Matheus Viezzer Bianchi 1 , Fernando Froner Argenta 1 , Bruna Correa Lopes 1 , Paula Augusto Taunde 1 , Paulo Guilherme Carniel Wagner 2 , David Driemeier 1 , Saulo Petinatti Pavarini 1 , Fabiana Quoos Mayer 3 , Franciele Maboni Siqueira 4 , Luciana Sonne 1
Affiliation  

Tuberculosis is a common zooanthroponosis in humans with a high incidence in Brazil, but it may also affect non-human primates (NHPs), of which Old World primates are most commonly involved. Nonetheless, its occurrence in New World primates is unknown, and therefore, this study aimed to describe the infection by Mycobacterium tuberculosis variant tuberculosis in two captive black capuchin monkeys (Sapajus nigritus) in Southern Brazil. The primates were housed in the same enclosure, wherein close contact with humans frequently occurred, and presented apathy, anorexia, and death in a clinical course of 15 days to 2 months. At the necropsy, the tracheobronchial lymph nodes were markedly enlarged and firm to hard and on the cut surface had a caseous aspect. The lungs exhibited two injury patterns: multifocal and disseminated. Microscopically, the lungs exhibited multifocal to coalescing necrotic granulomas and non-necrotic granulomas, with multiple acid-fast bacilli within the cytoplasm of epithelioid macrophages and multinucleated giant cells. Bacilli were also labeled upon immunohistochemistry (IHC) for Mycobacterium tuberculosis. Microbiological culture of lung samples from both cases yielded colonies compatible with M. tuberculosis. The isolates were identified as M. tuberculosis var. tuberculosis through polymerase chain reaction (PCR). Although tuberculosis is poorly described in New World primates, M. tuberculosis var. tuberculosis may cause a highly contagious and progressive disease with high mortality in black capuchin monkeys (S. nigritus).

中文翻译:

结核分枝杆菌变种 巴西南部两只圈养黑卷尾猴(Sapajus nigritus)的结核病感染

结核病是一种常见的人畜共患病,在巴西发病率很高,但它也可能影响非人类灵长类动物 (NHP),其中最常见的是旧大陆灵长类动物。尽管如此,它在新世界灵长类动物中的发生情况尚不清楚,因此,本研究旨在描述巴西南部两只圈养的黑卷尾猴(Sapajus nigritus)感染结核分枝杆菌变异型结核病的情况。灵长类动物被圈养在同一个笼子里,经常与人密切接触,在15天到2个月的临床过程中表现出冷漠、厌食和死亡。尸检时,气管支气管淋巴结明显肿大,变硬变硬,切面呈干酪样。肺表现出两种损伤模式:多灶性和播散性。微观上,肺表现出多灶性至融合性坏死性肉芽肿和非坏死性肉芽肿,上皮样巨噬细胞和多核巨细胞的细胞质内有多个抗酸杆菌。杆菌也被标记为结核分枝杆菌的免疫组织化学 (IHC)。来自两个病例的肺样本的微生物培养产生了与结核分枝杆菌相容的菌落。分离株被鉴定为结核分枝杆菌变种。结核分枝杆菌聚合酶链反应 (PCR)。虽然结核病在新世界灵长类动物中的描述很差,但结核分枝杆菌变种。结核分枝杆菌可能会在黑卷尾猴(S. nigritus)中引起具有高死亡率的高度传染性和进行性疾病。上皮样巨噬细胞和多核巨细胞的细胞质内含有多种抗酸杆菌。杆菌也被标记为结核分枝杆菌的免疫组织化学 (IHC)。来自两个病例的肺样本的微生物培养产生了与结核分枝杆菌相容的菌落。分离株被鉴定为结核分枝杆菌变种。结核分枝杆菌聚合酶链反应 (PCR)。虽然结核病在新世界灵长类动物中的描述很差,但结核分枝杆菌变种。结核分枝杆菌可能会在黑卷尾猴(S. nigritus)中引起具有高死亡率的高度传染性和进行性疾病。上皮样巨噬细胞和多核巨细胞的细胞质内含有多种抗酸杆菌。杆菌也被标记为结核分枝杆菌的免疫组织化学 (IHC)。来自两个病例的肺样本的微生物培养产生了与结核分枝杆菌相容的菌落。分离株被鉴定为结核分枝杆菌变种。结核分枝杆菌聚合酶链反应 (PCR)。虽然结核病在新世界灵长类动物中的描述很差,但结核分枝杆菌变种。结核分枝杆菌可能会在黑卷尾猴(S. nigritus)中引起具有高死亡率的高度传染性和进行性疾病。来自两个病例的肺样本的微生物培养产生了与结核分枝杆菌相容的菌落。分离株被鉴定为结核分枝杆菌变种。结核分枝杆菌聚合酶链反应 (PCR)。虽然结核病在新世界灵长类动物中的描述很差,但结核分枝杆菌变种。结核分枝杆菌可能会在黑卷尾猴(S. nigritus)中引起具有高死亡率的高度传染性和进行性疾病。来自两个病例的肺样本的微生物培养产生了与结核分枝杆菌相容的菌落。分离株被鉴定为结核分枝杆菌变种。结核分枝杆菌聚合酶链反应 (PCR)。虽然结核病在新世界灵长类动物中的描述很差,但结核分枝杆菌变种。结核分枝杆菌可能会在黑卷尾猴(S. nigritus)中引起具有高死亡率的高度传染性和进行性疾病。
更新日期:2020-07-22
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