More than 30 years ago Goadsby and Edvinsson revealed in their landmark experiments that calcitonin gene-related peptide (CGRP) plays an essential role in trigeminal communication (1). In the following years, research revealed that CGRP is not only released upon trigeminal activation but can also activate trigeminal neurons (2). In line with these findings, clinical studies showed that CGRP is released in spontaneous migraine (3,4) and cluster headache (5) attacks and that both headache syndromes can be triggered by infusion of CGRP (6,7) and treated by targeting the CGRP pathway (8–10).

中文翻译：

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降钙素基因相关肽的分析-有用和误导性发现之间的狭窄路径。

30多年前，Goadsby和Edvinsson在他们具有里程碑意义的实验中揭示，降钙素基因相关肽（CGRP）在三叉神经沟通中起着至关重要的作用（1）。在随后的几年中，研究表明CGRP不仅在三叉神经激活时释放，而且还可以激活三叉神经元（2）。根据这些发现，临床研究表明，CGRP在自发性偏头痛（3,4）和丛集性头痛（5）发作中释放，两种头痛综合征均可通过输注CGRP（6,7）触发，并通过靶向治疗CGRP途径（8-10）。