An efficient process for the synthesis of degradable hydrogels containing octa-betaine ester polyhedral oligomeric silsesquioxane (POSS) through efficient thiol–ene and Menschutkin click reactions was developed. The hydrogels exhibited a yield strength of 0.36 MPa and a compressive modulus of 4.38 MPa and displayed excellent flexibility as well as torsion resistance. Antibacterial efficacy of hydrogels (and degradation products) was evaluated using Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). Efficacy was found to increase with the concentration of cetyl chloroacetate (CCA) in the hydrogel network, reaching 93% and 99% for Escherichia coli and Staphylococcus aureus, respectively. Degradation of hydrogels was observed in weak alkali conditions (pH = 8) and at physiological conditions (pH = 7.4). The degradation time of the hydrogels could be finely tuned by variation of the CCA content in the hydrogel and environmental stimulus. The tunable degradation behavior under physiological conditions combined with high antibacterial efficacy could render the presented materials interesting for tissue engineering applications.

中文翻译：

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单击化学方法的抗菌和可降解的杂化水凝胶的八角-贝塔恩酯多面体寡聚倍半硅氧烷。

通过有效的硫醇-烯和Menschutkin点击反应，开发了一种有效的合成可降解水凝胶的方法，该凝胶包含八-甜菜碱酯多面体低聚倍半硅氧烷（POSS）。该水凝胶的屈服强度为0.36 MPa，压缩模量为4.38 MPa，并具有优异的柔韧性和抗扭转性。使用大肠杆菌（革兰氏阴性）和金黄色葡萄球菌（革兰氏阳性）评估水凝胶（和降解产物）的抗菌功效。发现功效随着水凝胶网络中氯乙酸十六烷基酯（CCA）浓度的增加而增加，对大肠杆菌和金黄色葡萄球菌分别达到93％和99％， 分别。在弱碱性条件下（pH = 8）和生理条件下（pH = 7.4）观察到水凝胶降解。水凝胶的降解时间可以通过水凝胶中CCA含量的变化和环境刺激来微调。在生理条件下的可调节降解行为与高抗菌功效相结合，可以使所提出的材料在组织工程应用中引起人们的兴趣。