Dual Photo- and pH-Responsive Spirooxazine-Functionalized Dextran Nanoparticles.,Biomacromolecules

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Dual Photo- and pH-Responsive Spirooxazine-Functionalized Dextran Nanoparticles.
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-07-20 , DOI: 10.1021/acs.biomac.0c00642
Shahnaz Rahimi _{1,

2} , Steffi Stumpf _{2,

3} , Oliver Grimm ₂ , Felix H Schacher _{2,

3} , Ulrich S Schubert _{2,

3} , Stephanie Schubert _{3,

4}

Affiliation

A dual photo- and pH-responsive spirooxazine-functionalized polymer was synthesized by functionalization of dextran with a spirooxazine derivative (SO-COOH). The functionalized dextran derivatives can form nanoparticles in aqueous medium. Under UV light irradiation, the spirooxazine-functionalized dextran (Dex-SO) nanoparticles isomerize to zwitterionic merocyanine-functionalized dextran (Dex-MC), which leads to aggregation. However, the process is reversible upon irradiation with visible light. Under acidic conditions, the hydrophobic spirooxazine is protonated, and the nanoparticles aggregate or swell at pH values of 5 or 3, respectively. The encapsulation of the hydrophobic fluorescent dye Nile Red as model drug allowed us to gain more information about the structural changes under stimulation of UV light and acid treatment.

中文翻译：

双重光响应和pH响应的螺恶嗪功能化的葡聚糖纳米颗粒。

通过用螺恶嗪衍生物（SO-COOH）对葡聚糖进行官能化，合成了对光和pH有响应的螺恶嗪功能化的聚合物。官能化的葡聚糖衍生物可以在水性介质中形成纳米颗粒。在紫外光照射下，螺恶嗪官能化的葡聚糖（Dex-SO）纳米颗粒异构化为两性离子型花菁官能化的葡聚糖（Dex-MC），这导致聚集。但是，该过程在可见光照射下是可逆的。在酸性条件下，疏水的螺恶嗪质子化，并且纳米颗粒分别在5或3的pH值下聚集或溶胀。疏水荧光染料尼罗红作为模型药物的包封使我们可以获得有关在紫外线和酸处理的刺激下结构变化的更多信息。

更新日期：2020-09-14

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