A multiplex assay for characterization of antimicrobial resistance in Neisseria gonorrhoeae using multi-PCR coupled with mass spectrometry.,Journal of Antimicrobial Chemotherapy

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A multiplex assay for characterization of antimicrobial resistance in Neisseria gonorrhoeae using multi-PCR coupled with mass spectrometry.
Journal of Antimicrobial Chemotherapy ( IF 3.9 ) Pub Date : 2020-07-20 , DOI: 10.1093/jac/dkaa269
Yamei Li _{1,

2} , Leshan Xiu _{1,

2} , Jingwei Liu _{3,

4} , Chi Zhang _{1,

2} , Feng Wang ₅ , Yueping Yin _{3,

4} , Junping Peng _{1,

2}

Affiliation

Complicated mechanisms and variable determinants related to drug resistance pose a major challenge to obtain comprehensive antimicrobial resistance (AMR) profiles of Neisseria gonorrhoeae. Meanwhile, cephalosporin-resistant mosaic penA alleles have been reported worldwide. Therefore, it is urgent to monitor the expansion of cephalosporin-resistant mosaic penA alleles.

中文翻译：

使用多重PCR和质谱联用技术对淋病奈瑟氏球菌的抗菌素耐药性进行多重分析。

要获得淋病奈瑟氏球菌的全面抗药性（AMR）资料，与耐药性相关的复杂机制和可变决定因素将是一个重大挑战。同时，全世界已经报道了对头孢菌素具有抗性的镶嵌penA等位基因。因此，迫切需要监测耐头孢菌素的花叶笔A等位基因的扩增。

更新日期：2020-09-20

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