Introduction: Eosinophilia (eosinophil fraction of leukocytes #x3e;5%), an indicative parameter for bioincompatibility in various circumstances, is well established in hemodialysis. However, change in eosinophil count (EOC) and its association with death-censored technique failure among peritoneal dialysis (PD) patients remain unclear. Methods: We compared eosinophils before and after PD initiation among 1,432 eligible continuous ambulatory PD patients regularly followed up in our PD center during 2007–2018. Risk factors of early-stage eosinophilia were examined by the logistic regression test. The relationship of early-stage eosinophilia and EOC with death-censored technique failure was examined using the Cox proportional hazards model for overall patients and for men and women separately. Results: After PD initiation, the EOC and percentage of patients with eosinophilia were significantly increased compared with baseline. Being male (odds ratio [OR]: 2.26; 95% confidence interval [CI]: 1.55–3.31; p #x3c; 0.001) and higher EOC at baseline (100 cells/μL increase, OR: 1.62; 95% CI: 1.45–1.82; p #x3c; 0.001) were risk factors of early-stage eosinophilia after PD initiation. During follow-up, 204 death-censored technique failures were recorded. In fully adjusted models, each with 100 cells/μL increase in EOC, the adjusted hazard ratios (HRs) of technique failure were 1.11 (95% CI: 1.03–1.20; p = 0.009) in the whole cohort, 1.29 (95% CI: 1.10–1.51; p = 0.002) in women, and 1.07 (95% CI: 0.97–1.17; p = 0.196) in men. Eosinophilia was significantly associated with the risk of technique failure for women (HR: 2.24; 95% CI: 1.07–4.70; p = 0.033), which was especially significant for women aged #x3c;55 years (HR: 7.61; 95% CI: 1.88–30.90; p = 0.005). Conclusion: EOC was increased significantly after PD initiation, and increased numbers of eosinophils were associated with higher death-censored technique failure in PD patients, especially women.
Int Arch Allergy Immunol

中文翻译：

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较高的嗜酸性粒细胞可预测腹膜透析患者的死亡检查技术失败。

简介：血液透析中已经建立了嗜酸性粒细胞增多（嗜酸性粒细胞比例为白细胞的嗜酸性粒细胞含量＃x3e; 5％），它是各种情况下生物相容性的指标。然而，尚不清楚腹膜透析（PD）患者中嗜酸性粒细胞计数（EOC）的变化及其与死亡检查技术失败的关系。方法：我们比较了2007年至2018年在我们PD中心定期随访的1,432例符合条件的连续性非卧床PD患者中，在PD始发之前和之后的嗜酸性粒细胞。早期嗜酸性粒细胞增多的危险因素通过逻辑回归检验进行了检验。使用Cox比例风险模型对整体患者和男性和女性分别检查了早期嗜酸性粒细胞增多和EOC与死亡检查技术失败的关系。结果： PD引发后，嗜酸细胞增多症患者的EOC和百分比与基线相比显着增加。是男性（比值[OR]：2.26； 95％置信区间[CI]：1.55-3.31； p＃x3c； 0.001），基线时的EOC较高（增加100个细胞/μL，OR：1.62；95% CI：1.45 –1.82； p＃x3c； 0.001）是PD引发后早期嗜酸性粒细胞增多的危险因素。在随访期间，记录了204例以死亡检查的技术失败。在完全调整的模型中，每个模型的EOC增加100个细胞/μL，在整个队列中，技术失败的调整后危险比（HRs）为1.11（95％CI：1.03-1.20; p = 0.009），而整个队列为1.29（95％CI ：女性为1.10–1.51； p = 0.002），女性为1.07（95％CI：0.97–1.17；p = 0.196）。嗜酸性粒细胞增多与女性技术失败的风险显着相关（HR：2.24； 95％CI：1.07–4.70；p = 0.033），这对于55岁以下的女性尤为显着（HR：7.61； 95％CI ：1.88–30.90；p = 0.005）。结论： PD发作后EOC显着增加，并且嗜酸性粒细胞数量增加与PD患者（尤其是女性）的更高的以死亡为前提的检查失败技术失败相关。
Int Arch过敏免疫