Abstract An efficient method for the large-scale fabrication of composite polyvinyl alcohol polymer nano fibers loaded with magnetic nanoparticles and methotrexate is reported in this study. We have demonstrated that nonwoven textile formed by needleless electro spinning is effective in immobilization and triggered the release of drugs, which is achieved by an alternating magnetic field induced heating of magnetic nanoparticles. This smart stimuli-responsive release ability, biocompatibility, and ultra-lightweight property render enormous potential for this electrospun nano fiber mat to be used as an anti-psoriatic drugs release platform, which may have far-reaching applications in dermatology.

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电纺复合纳米纤维的远程磁控药物释放：设计用于治疗银屑病的智能平台

摘要 本研究报道了一种大规模制备负载磁性纳米粒子和甲氨蝶呤的复合聚乙烯醇聚合物纳米纤维的有效方法。我们已经证明，通过无针静电纺丝形成的非织造织物可有效固定并触发药物的释放，这是通过交变磁场感应加热磁性纳米颗粒来实现的。这种智能刺激响应释放能力、生物相容性和超轻质特性为这种电纺纳米纤维垫用作抗银屑病药物释放平台提供了巨大的潜力，这可能在皮肤病学中具有深远的应用。