Dim light at night exacerbates stroke outcome,European Journal of Neuroscience

当前位置： X-MOL 学术 › Eur. J. Neurosci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Dim light at night exacerbates stroke outcome
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-07-21 , DOI: 10.1111/ejn.14915
Zachary M. Weil ₁ , Laura K. Fonken ₂ , William H. Walker ₁ , Jacob R. Bumgarner ₁ , Jennifer A. Liu ₁ , O. Hecmarie Melendez‐Fernandez ₁ , Ning Zhang ₁ , A. Courtney DeVries _{1,

3} , Randy J. Nelson ₁

Affiliation

Circadian rhythms are endogenous biological cycles that synchronize physiology and behaviour to promote optimal function. These ~24‐hr internal rhythms are set to precisely 24 hr daily by exposure to the sun. However, the prevalence of night‐time lighting has the potential to dysregulate these biological functions. Hospital patients may be particularly vulnerable to the consequences of light at night because of their compromised physiological state. A mouse model of stroke (middle cerebral artery occlusion; MCAO) was used to test the hypothesis that exposure to dim light at night impairs responses to a major insult. Stroke lesion size was substantially larger among animals housed in dLAN after reperfusion than animals maintained in dark nights. Mice housed in dLAN for three days after the stroke displayed increased post‐stroke anxiety‐like behaviour. Overall, dLAN amplified pro‐inflammatory pathways in the CNS, which may have exacerbated neuronal damage. Our results suggest that exposure to LAN is detrimental to stroke recovery.

中文翻译：

夜间昏暗的光线加剧中风的后果

昼夜节律是内源性生物周期，可同步生理和行为以促进最佳功能。通过暴露在阳光下，这些〜24小时的内部节奏每天精确地设置为24小时。但是，夜间照明的盛行有可能使这些生物学功能失调。住院患者由于生理状态受损，可能特别容易受到夜间光照的影响。中风的小鼠模型（大脑中动脉闭塞； MCAO）用于检验以下假设：夜间暴露于昏暗的光线会削弱对重大损伤的反应。再灌注后安置在dLAN中的动物的中风病灶大小要比漆黑的夜晚大得多。中风后在dLAN中呆了三天的小鼠表现出中风后焦虑样行为增加。总体而言，dLAN放大了中枢神经系统中的促炎途径，这可能加剧了神经元损伤。我们的结果表明，暴露于LAN对中风恢复有害。

更新日期：2020-07-21

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11