A new series of 2‐(4‐(benzo[d]thiazol‐5‐ylsulfonyl)piperazin‐1‐yl)‐N‐substituted acetamide (5a‐5k) compounds have been synthesized, and these compounds were characterized with spectral data like IR, NMR, and Mass spectroscopy. All compounds were evaluated in vitro for their efficacy as antimicrobial against Gram‐positive and Gram‐negative pathogenic bacterial strains such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa using ciprofloxacin as a standard and fungal strains like Candida albicans and Aspergillus fumigatus as compared with standard drug Clotrimazole, and Molecular docking study shows that all these compounds were having good to excellent correlation binding energy as compared with binding energy of standard drugs.

中文翻译：

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2-（4-（苯并[d]噻唑-5-基磺酰基）哌嗪-1-基）-N-取代的乙酰胺衍生物的合成及抑菌活性

合成了一系列新的2-（4-（苯并[d]噻唑-5-基磺酰基）哌嗪-1-基）-N-取代的乙酰胺（5a-5k）化合物，这些化合物的光谱数据诸如红外，核磁共振和质谱。使用环丙沙星作为标准品和白色念珠菌和白色曲霉等真菌菌株，体外评估所有化合物作为抗革兰氏阳性和革兰氏阴性致病细菌菌株（如金黄色葡萄球菌，枯草芽孢杆菌，大肠杆菌和铜绿假单胞菌）的抗微生物剂的功效。 与标准药物克霉唑相比，分子对接研究表明，与标准药物的结合能相比，所有这些化合物均具有良好的相关结合能。