Control the Mechanical Properties and Degradation of Poly(Glycerol Sebacate) by Substitution of the Hydroxyl Groups with Palmitates,Macromolecular Bioscience

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Control the Mechanical Properties and Degradation of Poly(Glycerol Sebacate) by Substitution of the Hydroxyl Groups with Palmitates
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-07-20 , DOI: 10.1002/mabi.202000101
Xiaochu Ding ₁ , Ying Chen ₁ , Corson Andrew Chao ₁ , Yen-Lin Wu ₁ , Yadong Wang ₁

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Mechanical properties and degradation profile are important parameters for the applications of biodegradable polyester such as poly(glycerol sebacate) in biomedical engineering. Here, a strategy is reported to make palmitate functionalized poly(glycerol sebacate) (PPGS) to alter the polymer hydrophobicity, crystallinity, microstructures and thermal properties. The changes of these intrinsic properties impart tunable degradation profiles and mechanical properties to the resultant elastomers depending on the palmitate contents. When the palmitates reach up to 16 mol%, the elastic modulus is tuned from initially 838 ± 55 kPa for the PGS to 333 ± 21 kPa for the PPGS under the same crosslinking conditions. The elastomer undergoes reversible elastic deformations for at least 1000 cycles within 20% strain without failure and shows enhanced elasticity. The polymer degradation is simultaneously inhibited because of the increased hydrophobicity. This strategy is different with other PGS modifications which could form a softer elastomer with less crosslinks but typically lead to a quicker degradation. Because the materials are made from endogenous molecules, they possess good cytocompatibility similar to the PGS control. Although these materials are designed specifically for small arteries, it is expected that they will be useful for other soft tissues too.

中文翻译：

通过用棕榈酸酯取代羟基来控制聚（甘油癸二酸酯）的机械性能和降解

机械性能和降解曲线是生物可降解聚酯（如聚甘油癸二酸酯）在生物医学工程中应用的重要参数。在这里，报道了一种策略，使棕榈酸酯功能化的聚（甘油癸二酸酯）（PPGS）改变聚合物的疏水性、结晶度、微观结构和热性能。根据棕榈酸酯含量，这些固有特性的变化赋予所得弹性体可调的降解曲线和机械特性。当棕榈酸酯达到 16 mol% 时，在相同交联条件下，弹性模量从最初的 PGS 的 838 ± 55 kPa 调整到 PPGS 的 333 ± 21 kPa。弹性体在 20% 应变内经历至少 1000 次循环的可逆弹性变形而不会失效，并显示出增强的弹性。由于增加的疏水性，聚合物降解同时被抑制。这种策略与其他 PGS 改性不同，后者可以形成具有较少交联的较软弹性体，但通常会导致更快的降解。由于材料由内源性分子制成，因此它们具有与 PGS 对照类似的良好细胞相容性。虽然这些材料是专门为小动脉设计的，但预计它们也可用于其他软组织。它们具有与 PGS 对照相似的良好细胞相容性。虽然这些材料是专门为小动脉设计的，但预计它们也可用于其他软组织。它们具有与 PGS 对照相似的良好细胞相容性。虽然这些材料是专门为小动脉设计的，但预计它们也可用于其他软组织。

更新日期：2020-07-20

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