Comparative study of the phenolic profile, antioxidant properties, and inhibitory effects of Moringa (Moringa oleifera Lam.) and Almond (Terminalia catappa Linn.) leaves on acetylcholinesterase and monoamine oxidase activities in the head region of Fruitfly (Drosophila melanogaster Meigen) in vitro,Journal of Food Biochemistry

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Comparative study of the phenolic profile, antioxidant properties, and inhibitory effects of Moringa (Moringa oleifera Lam.) and Almond (Terminalia catappa Linn.) leaves on acetylcholinesterase and monoamine oxidase activities in the head region of Fruitfly (Drosophila melanogaster Meigen) in vitro
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-07-21 , DOI: 10.1111/jfbc.13401
Olubukola H Oyeniran _{1,

2} , Adedayo O Ademiluyi ₁ , Ganiyu Oboh ₁

Affiliation

Moringa and Almond are medicinal plants used traditionally as food and medicine to prevent and/or treat a wide array of metabolic and neurodegenerative diseases, however, Almond leaf is underutilized. Therefore, this study investigated and compared the polyphenol constituents, antioxidant capacities, and neurochemical indices of the aqueous extracts of Moringa and Almond leaves in fruitfly head tissue homogenate in vitro. The polyphenols were evaluated by characterization using HPLC‐DAD, antioxidant properties were assessed through extracts ability to inhibit ABTS, DPPH, OH, and NO radicals, reduce Fe³⁺ and MDA, and chelate Fe²⁺. The neurochemical indices were evaluated through AChE and MAO inhibitory activities. Almond leaf had significant (p < .05) higher polyphenols and antioxidant properties. However, Moringa leaf had significant (p < .05) higher AChE inhibition and no significant (p < .05) difference was obtained in MAO inhibitory activities. Thus, Almond leaf might be more effective in managing diseases related with oxidative stress and neurodegeneration.

中文翻译：

辣木（Moringa oleifera Lam。）和杏仁（Terminalia catappa Linn。）叶片对果蝇（Drosophila melanogaster Meigen）头部乙酰胆碱酯酶和单胺氧化酶活性的体外酚类特征，抗氧化性能和抑制作用的比较研究

辣木和杏仁是传统上用作食品和药物以预防和/或治疗多种代谢和神经退行性疾病的药用植物，但是杏仁叶的利用不足。因此，本研究调查并比较了果蝇头组织匀浆中辣木和杏仁叶水提取物的多酚成分，抗氧化能力和神经化学指标。通过使用HPLC-DAD进行表征来评估多酚，通过提取物抑制ABTS，DPPH，OH和NO自由基，还原Fe ³⁺和MDA以及螯合Fe ^2+的能力来评估抗氧化性能。通过AChE和MAO抑制活性评估神经化学指标。杏仁叶有显着性（p <.05）更高的多酚和抗氧化性能。然而，辣木叶具有显著（p <0.05）更高的AChE抑制和无显著（p 在MAO抑制活性得到<0.05）差异。因此，杏仁叶可能在处理与氧化应激和神经退行性疾病有关的疾病方面更为有效。

更新日期：2020-07-21

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