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Viruses and asthma: the role of common respiratory viruses in asthma and its potential meaning for SARS-CoV-2.
Immunology ( IF 4.9 ) Pub Date : 2020-07-20 , DOI: 10.1111/imm.13240 Natalija Novak 1 , Beatriz Cabanillas 2
Immunology ( IF 4.9 ) Pub Date : 2020-07-20 , DOI: 10.1111/imm.13240 Natalija Novak 1 , Beatriz Cabanillas 2
Affiliation
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Viral infections and atopic diseases are closely related and contribute to each other. The physiological deficiencies and immune mechanisms that underlie atopic diseases can result in a suboptimal defense against multiple viruses, and promote a suitable environment for their proliferation and dissemination. Viral infections, on the other hand, can induce per se several immunological mechanisms involved in allergic inflammation capable to promote the initiation or exacerbation of atopic diseases such as atopic asthma. In a world that is affected more and more by factors that significantly impact the prevalence of atopic diseases, coronavirus disease 2019 (COVID‐19) induced by the novel coronavirus severe acute respiratory syndrome (SARS‐CoV‐2) is having an unprecedented impact with still unpredictable consequences. Therefore, it is of crucial importance to revise the available scientific literature regarding the association between common respiratory viruses and asthma, as well as the newly emerging data about the molecular mechanisms of SARS‐CoV‐2 infection and its possible relation with asthma, to better understand the interrelation between common viruses and asthma and its potential meaning on the current global pandemic of COVID‐19.
中文翻译：
病毒与哮喘：常见呼吸道病毒在哮喘中的作用及其对 SARS-CoV-2 的潜在意义。
病毒感染和特应性疾病密切相关且相互影响。特应性疾病背后的生理缺陷和免疫机制可能导致对多种病毒的防御不佳，并促进其增殖和传播的合适环境。另一方面，病毒感染本身可以诱导涉及过敏性炎症的几种免疫学机制，能够促进特应性疾病例如特应性哮喘的发生或恶化。在一个越来越受到显着影响特应性疾病患病率的因素影响的世界中，由新型冠状病毒严重急性呼吸综合征（SARS-CoV-2）引起的 2019 年冠状病毒病（COVID-19）正在对人们产生前所未有的影响。后果仍难以预料。因此，修订有关常见呼吸道病毒与哮喘之间关系的现有科学文献，以及有关 SARS-CoV-2 感染的分子机制及其与哮喘可能关系的新数据，至关重要。了解常见病毒与哮喘之间的相互关系及其对当前 COVID-19 全球大流行的潜在意义。
更新日期：2020-09-18
中文翻译：
病毒与哮喘：常见呼吸道病毒在哮喘中的作用及其对 SARS-CoV-2 的潜在意义。
病毒感染和特应性疾病密切相关且相互影响。特应性疾病背后的生理缺陷和免疫机制可能导致对多种病毒的防御不佳，并促进其增殖和传播的合适环境。另一方面，病毒感染本身可以诱导涉及过敏性炎症的几种免疫学机制，能够促进特应性疾病例如特应性哮喘的发生或恶化。在一个越来越受到显着影响特应性疾病患病率的因素影响的世界中，由新型冠状病毒严重急性呼吸综合征（SARS-CoV-2）引起的 2019 年冠状病毒病（COVID-19）正在对人们产生前所未有的影响。后果仍难以预料。因此，修订有关常见呼吸道病毒与哮喘之间关系的现有科学文献，以及有关 SARS-CoV-2 感染的分子机制及其与哮喘可能关系的新数据，至关重要。了解常见病毒与哮喘之间的相互关系及其对当前 COVID-19 全球大流行的潜在意义。
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