The finding that γδ T cells are present among tumor‐infiltrating lymphocytes in humans suggests they participate in tumor immune surveillance, but their relevance is unclear because the relative abundance of tumor‐infiltrating γδ T cells correlates with positive or negative, or even do not correlate with prognosis. This likely depends on the fact that tumor‐infiltrating γδ T cells may play substantially different effector or regulatory functions, and correlation with patient's prognosis relies on distinct γδ T cell subsets in the context of the tumor. There is interest to exploit γδ T cells in tumor immunotherapy, but to make this approach successful there is urgent need to fully understand the biological functions of γδ T cells and of how they can be manipulated in vivo and ex vivo to safely provide benefit to the host. This review focuses on our previous and ongoing studies of tumor‐infiltrating γδ T lymphocytes in different types of human cancer. Moreover, we discuss the interaction of tumor‐infiltrating γδ T cells with other cells and molecules present in the tumor microenvironment, and their clinical relevance on the ground, that deep knowledge in this field can be used further for better immunotherapeutic intervention in cancer.

中文翻译：

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解读癌症中的人类 γδ T 细胞反应：来自肿瘤浸润 γδ T 细胞的经验教训。

γδ T 细胞存在于人类肿瘤浸润淋巴细胞中的发现表明它们参与肿瘤免疫监视，但它们的相关性尚不清楚，因为肿瘤浸润 γδ T 细胞的相对丰度与阳性或阴性相关，甚至不相关与预后。这可能取决于肿瘤浸润性 γδ T 细胞可能发挥显着不同的效应或调节功能这一事实，并且与患者预后的相关性依赖于肿瘤背景下不同的 γδ T 细胞亚群。在肿瘤免疫治疗中利用 γδ T 细胞是有兴趣的，但为了使这种方法成功，迫切需要充分了解 γδ T 细胞的生物学功能以及如何在体内和体外操纵它们以安全地为主持人。本综述侧重于我们之前和正在进行的对不同类型人类癌症中肿瘤浸润 γδ T 淋巴细胞的研究。此外，我们讨论了肿瘤浸润性 γδ T 细胞与肿瘤微环境中存在的其他细胞和分子的相互作用，以及它们在实地的临床相关性，该领域的深入知识可以进一步用于更好地对癌症进行免疫治疗干预。