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Dim light at night exacerbates stroke outcome.
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-07-21 , DOI: 10.1111/ejn.14915 Zachary M Weil 1 , Laura K Fonken 2 , William H Walker 1 , Jacob R Bumgarner 1 , Jennifer A Liu 1 , O Hecmarie Melendez-Fernandez 1 , Ning Zhang 1 , A Courtney DeVries 1, 3 , Randy J Nelson 1
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-07-21 , DOI: 10.1111/ejn.14915 Zachary M Weil 1 , Laura K Fonken 2 , William H Walker 1 , Jacob R Bumgarner 1 , Jennifer A Liu 1 , O Hecmarie Melendez-Fernandez 1 , Ning Zhang 1 , A Courtney DeVries 1, 3 , Randy J Nelson 1
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Circadian rhythms are endogenous biological cycles that synchronize physiology and behaviour to promote optimal function. These ~24‐hr internal rhythms are set to precisely 24 hr daily by exposure to the sun. However, the prevalence of night‐time lighting has the potential to dysregulate these biological functions. Hospital patients may be particularly vulnerable to the consequences of light at night because of their compromised physiological state. A mouse model of stroke (middle cerebral artery occlusion; MCAO) was used to test the hypothesis that exposure to dim light at night impairs responses to a major insult. Stroke lesion size was substantially larger among animals housed in dLAN after reperfusion than animals maintained in dark nights. Mice housed in dLAN for three days after the stroke displayed increased post‐stroke anxiety‐like behaviour. Overall, dLAN amplified pro‐inflammatory pathways in the CNS, which may have exacerbated neuronal damage. Our results suggest that exposure to LAN is detrimental to stroke recovery.
中文翻译：
夜间昏暗的灯光会加剧中风的后果。
昼夜节律是内源性生物周期，它使生理和行为同步以促进最佳功能。这些约 24 小时的内部节律通过暴露在阳光下精确地设置为每天 24 小时。然而，夜间照明的普遍存在可能会导致这些生物功能失调。由于生理状态受损，医院患者可能特别容易受到夜间光线的影响。使用中风小鼠模型（大脑中动脉闭塞；MCAO）来检验夜间暴露在昏暗光线下会损害对重大损伤的反应的假设。再灌注后饲养在 dLAN 中的动物中风病变的大小明显大于饲养在黑夜中的动物。中风后在 dLAN 中饲养三天的小鼠表现出中风后焦虑样行为的增加。总体而言，dLAN 放大了中枢神经系统中的促炎症通路，这可能加剧了神经元损伤。我们的结果表明，暴露于 LAN 不利于中风康复。
更新日期：2020-07-21
中文翻译：
夜间昏暗的灯光会加剧中风的后果。
昼夜节律是内源性生物周期，它使生理和行为同步以促进最佳功能。这些约 24 小时的内部节律通过暴露在阳光下精确地设置为每天 24 小时。然而，夜间照明的普遍存在可能会导致这些生物功能失调。由于生理状态受损，医院患者可能特别容易受到夜间光线的影响。使用中风小鼠模型（大脑中动脉闭塞；MCAO）来检验夜间暴露在昏暗光线下会损害对重大损伤的反应的假设。再灌注后饲养在 dLAN 中的动物中风病变的大小明显大于饲养在黑夜中的动物。中风后在 dLAN 中饲养三天的小鼠表现出中风后焦虑样行为的增加。总体而言，dLAN 放大了中枢神经系统中的促炎症通路，这可能加剧了神经元损伤。我们的结果表明，暴露于 LAN 不利于中风康复。
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