The effects of a single‐session cathodal transcranial pulsed current stimulation on corticospinal excitability: A randomized sham‐controlled double‐blinded study,European Journal of Neuroscience

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The effects of a single‐session cathodal transcranial pulsed current stimulation on corticospinal excitability: A randomized sham‐controlled double‐blinded study
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-07-21 , DOI: 10.1111/ejn.14916
Thusharika Dissanayaka ₁ , Maryam Zoghi ₂ , Michael Farrell _{3,

4} , Gary Egan ₃ , Shapour Jaberzadeh ₁

Affiliation

Transcranial pulsed current stimulation (tPCS) of the human motor cortex has received much attention in recent years. Although the effect of anodal tPCS with different frequencies has been investigated, the effect of cathodal tPCS (c‐tPCS) has not been explored yet. Therefore, the aim of the present study was to investigate the effect of c‐tPCS at 4 and 75 Hz frequencies on corticospinal excitability (CSE) and motor performance. In a randomized sham‐controlled crossover design, fifteen healthy participants attended three experimental sessions and received either c‐tPCS at 75 Hz, 4 Hz or sham with 1.5 mA for 15 min. Transcranial magnetic stimulation and grooved pegboard test were performed before, immediately after and 30 min after the completion of stimulation at rest. The findings indicate that c‐tPCS at both 4 and 75 Hz significantly increased CSE compared to sham. Both c‐tPCS at 75 and 4 Hz showed a significant increase in intracortical facilitation compared to sham, whereas the effect on short‐interval intracortical inhibition was not significant. The c‐tPCS at 4 Hz but not 75 Hz induced modulation of intracortical facilitation correlated with the CSE. Motor performance did not show any significant changes. These results suggest that, compared with sham stimulation, c‐tPCS at both 4 and 75 Hz induces an increase in CSE.

中文翻译：

单阶段阴极经颅脉冲电流刺激对皮质脊髓兴奋性的影响：一项随机假手术双盲研究

近年来，人类运动皮层的经颅脉冲电流刺激（tPCS）受到了广泛关注。尽管已研究了不同频率的阳极tPCS的影响，但尚未探索阴极tPCS（c-tPCS）的影响。因此，本研究的目的是研究在4 Hz和75 Hz频率下c-tPCS对皮质脊髓兴奋性（CSE）和运动性能的影响。在随机的假手术控制交叉设计中，十五名健康的参与者参加了三个实验会议，并接受了75 Hz，4 Hz的c-tPCS或1.5 mA的假手术15分钟。在静息刺激完成之前，之后和之后30分钟分别进行经颅磁刺激和沟槽钉板试验。研究结果表明，与伪造相比，c-tPCS在4 Hz和75 Hz时均显着提高了CSE。与假手术相比，在75 Hz和4 Hz的c-tPCS均显示皮层内促进作用明显增加，而对短间隔皮层内抑制作用不明显。c-tPCS在4 Hz而不是75 Hz时诱导皮层内促进的调制与CSE相关。电机性能未显示任何重大变化。这些结果表明，与假刺激相比，c-tPCS在4 Hz和75 Hz时均会导致CSE升高。c-tPCS在4 Hz而不是75 Hz时诱导皮层内促进的调制与CSE相关。电机性能未显示任何重大变化。这些结果表明，与假刺激相比，c-tPCS在4 Hz和75 Hz时均会导致CSE升高。c-tPCS在4 Hz而不是75 Hz时诱导皮层内促进的调制与CSE相关。电机性能未显示任何重大变化。这些结果表明，与假刺激相比，c-tPCS在4 Hz和75 Hz时均会导致CSE升高。

更新日期：2020-07-21

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