Phthalates and bisphenols are high production volume chemicals that are used in the manufacturing of consumer and medical products. Given the ubiquity of bisphenol and phthalate chemicals in the environment, biomonitoring studies routinely detect these chemicals in 75–90% of the general population. Accumulating evidence suggests that such chemical exposures may influence human health outcomes, including cardiovascular health. These associations are particularly worrisome for sensitive populations, including fetal, infant and pediatric groups—with underdeveloped metabolic capabilities and developing organ systems. In the presented article, we aimed to review the literature on environmental and clinical exposures to bisphenols and phthalates, highlight experimental work that suggests that these chemicals may exert a negative influence on cardiovascular health, and emphasize areas of concern that relate to vulnerable pediatric groups. Gaps in our current knowledge are also discussed, so that future endeavors may resolve the relationship between chemical exposures and the impact on pediatric cardiovascular physiology.

中文翻译：

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双酚和邻苯二甲酸盐：塑料化学品接触会导致不利的心血管健康结果。

邻苯二甲酸盐和双酚是用于制造消费品和医疗产品的高产量化学品。鉴于双酚和邻苯二甲酸盐化学品在环境中无处不在，生物监测研究通常会在 75-90% 的普通人群中检测到这些化学品。越来越多的证据表明，此类化学品暴露可能会影响人类健康结果，包括心血管健康。这些关联对于敏感人群尤其令人担忧，包括胎儿、婴儿和儿科人群——代谢能力不发达且器官系统发育。在本文中，我们旨在回顾有关双酚和邻苯二甲酸酯的环境和临床暴露的文献，强调表明这些化学物质可能对心血管健康产生负面影响的实验工作，并强调与弱势儿科群体相关的关注领域。还讨论了我们目前知识中的差距，以便未来的努力可以解决化学品暴露与对小儿心血管生理学影响之间的关系。