Opto-E-Dura: A Soft, Stretchable ECoG Array for Multimodal, Multiscale Neuroscience.,Advanced Healthcare Materials

当前位置： X-MOL 学术 › Adv. Healthcare Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Opto-E-Dura: A Soft, Stretchable ECoG Array for Multimodal, Multiscale Neuroscience.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-07-21 , DOI: 10.1002/adhm.202000814
Aline F Renz ₁ , Jihyun Lee ₁ , Klas Tybrandt _{1,

2} , Maciej Brzezinski ₁ , Dayra A Lorenzo _{3,

4} , Mouna Cerra Cheraka ₁ , Jaehong Lee ₁ , Fritjof Helmchen _{3,

4} , Janos Vörös _{1,

4} , Christopher M Lewis ₃

Affiliation

Soft, stretchable materials hold great promise for the fabrication of biomedical devices due to their capacity to integrate gracefully with and conform to biological tissues. Conformal devices are of particular interest in the development of brain interfaces where rigid structures can lead to tissue damage and loss of signal quality over the lifetime of the implant. Interfaces to study brain function and dysfunction increasingly require multimodal access in order to facilitate measurement of diverse physiological signals that span the disparate temporal and spatial scales of brain dynamics. Here the Opto‐e‐Dura, a soft, stretchable, 16‐channel electrocorticography array that is optically transparent is presented. Its compatibility with diverse optical and electrical readouts is demonstrated enabling multimodal studies that bridge spatial and temporal scales. The device is chronically stable for weeks, compatible with wide‐field and 2‐photon calcium imaging and permits the repeated insertion of penetrating multielectrode arrays. As the variety of sensors and effectors realizable on soft, stretchable substrates expands, similar devices that provide large‐scale, multimodal access to the brain will continue to improve fundamental understanding of brain function.

中文翻译：

Opto-E-Dura：适用于多模式，多尺度神经科学的柔软，可拉伸的ECoG阵列。

柔软，可拉伸的材料因具有与生物组织完美融合并顺应生物组织的能力而在制造生物医学设备方面具有广阔的前景。在大脑接口的开发中，保形设备特别受关注，在这种接口中，刚性结构可能会导致植入物整个生命周期内组织损伤和信号质量下降。研究脑功能和功能障碍的接口越来越需要多模式访问，以便于测量跨越脑动力学不同时空尺度的各种生理信号。在这里展示了Opto-e-Dura，它是一种柔软，可拉伸的16通道电皮层成像阵列，具有光学透明性。证明了其与各种光学和电子读数的兼容性，从而可以实现跨时空尺度的多峰研究。该设备可长期稳定运行数周，与宽视野和2光子钙成像兼容，并允许重复插入穿透性多电极阵列。随着在柔软，可拉伸的基板上可实现的各种传感器和效应器的扩展，提供大规模，多模式进入大脑的类似设备将继续改善对大脑功能的基本了解。

更新日期：2020-09-10

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11