Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a strain of coronavirus that causes coronavirus disease 2019 (Covid-19) and has been declared a global pandemic by the World Health Organization. Total cases of SARS-CoV-2 worldwide exceed 10.2 million, with over 503,000 deaths recorded. Little is known about the body's immune response to SARS-CoV-2 infection. In this paper, we describe SARS-CoV-2 IgG antibody responses in 28,523 patients from the New York City metropolitan area and report a SARS-CoV-2 IgG positivity rate of 44%, indicating the widespread nature of the pandemic in the city and state of New York. Additionally, for a subset of patients, we report on the correlation between SARS-CoV-2 patient symptom severity and level of SARS-CoV-2 IgG antibody found in the patient sample.

严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）是一种冠状病毒毒株，可导致2019年冠状病毒病（Covid-19），并已被世界卫生组织宣布为全球大流行病。全球SARS-CoV-2病例总数超过1020万，记录的死亡人数超过503,000。关于机体对SARS-CoV-2感染的免疫反应知之甚少。在本文中，我们描述了来自纽约市大都会地区的28,523名患者的SARS-CoV-2 IgG抗体应答，并报告SARS-CoV-2 IgG阳性率为44％，表明该大流行在该市和纽约州。此外，对于一部分患者，我们报告了SARS-CoV-2患者症状严重程度与患者样品中发现的SARS-CoV-2 IgG抗体水平之间的相关性。