Introducing functional metal nanoparticles (NPs) into flexible substrate is being increasingly attempted to expand their application. Here, we extend the synthesis of cellulose to its unmodified dope achieving freestanding nanocomposite decorated with bimetallic Ag-Au NPs through the one pot reaction. In the procedure, cellulose chain not only acts as a reducing agent but also a biocompatible support for NPs with a mean size of 7.9–9.7 nm. Meanwhile, changing the addition order of Ag⁺ and AuCl₄⁻ generated different atom arrangement in the bimetallic NPs. Moreover, the correlation of bioactivity to NP atom arrangement was studied. The result revealed that the nanocomposite containing NPs with an ultrathin Ag-rich outermost shell around an Au-rich core showed better bactericidal ability while lower cytotoxicity. In addition, the nanocomposite exhibited a sensitive SERS property for determination of R6G with a high enhancement factor of 10⁸.

越来越多地尝试将功能性金属纳米颗粒（NPs）引入柔性基板，以扩展其应用范围。在这里，我们将纤维素的合成扩展到其未修饰的涂料，通过一锅法反应实现了由双金属Ag-Au NPs装饰的独立纳米复合材料。在该程序中，纤维素链不仅充当还原剂，而且还为平均大小为7.9–9.7 nm的NP提供生物相容性支持。同时，改变Ag的添加顺序⁺和AUCL ₄ ^-在双金属NP中产生了不同的原子排列。此外，研究了生物活性与NP原子排列的相关性。结果表明，纳米复合材料包含纳米颗粒，纳米颗粒在富金核心周围具有最薄的富银外壳，表现出更好的杀菌能力，同时具有较低的细胞毒性。此外，该纳米复合材料对R6G的测定具有敏感的SERS特性，具有10 ⁸的高增强因子。