Background

Alcohol consumption is associated with hypertension, and this association depends on the alcohol consumption pattern and alcohol flushing response. In this 12-year follow-up study, we investigated the relationship between the alcohol consumption pattern and incidence of hypertension in the Korean population.

Methods

We analyzed 1,366 Korean participants in the Ansung–Ansan cohort study without hypertension at baseline. The subjects were classified into four alcohol consumption patterns: never-drinking, light alcohol consumption, moderate alcohol consumption, and heavy alcohol consumption, and as flushers or non-flushers in response to alcohol.

Results

In flushers, moderate and heavy alcohol consumption patterns increased the risk of incident hypertension compared with never-drinkers [moderate: HR 1.811 (95% CI 1.084–3.028); heavy: HR 2.494 (95% CI 1.185–5.247)], but non-flushers were not associated with increased risk of incident hypertension according to the alcohol consumption pattern. In addition, a heavy alcohol consumption pattern increased the risk of hypertension among flushers compared with non-flushers [HR 2.232 (95% CI 1.054–4.728)].

Conclusion

In this 12-year follow-up study, we observed that moderate and heavy alcohol consumption was associated with an increased risk of hypertension in flushers. Especially, a heavy alcohol consumption pattern in flushers markedly increased the risk of hypertension.

中文翻译：

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高血压发病率和饮酒模式与酒精潮红反应之间的关联：一项为期 12 年的随访研究。

背景

饮酒与高血压有关，这种关联取决于饮酒模式和酒精潮红反应。在这项为期 12 年的随访研究中，我们调查了韩国人群饮酒模式与高血压发病率之间的关系。

方法

我们在 Ansung-Ansan 队列研究中分析了 1,366 名基线时没有高血压的韩国参与者。受试者被分为四种饮酒模式：从不饮酒、轻度饮酒、中度饮酒和重度饮酒，以及对酒精的反应为潮红或不潮红。

结果

与从不喝酒的人相比，在潮红者中，中度和重度饮酒模式增加了发生高血压的风险[中度：HR 1.811 (95% CI 1.084–3.028)；重度：HR 2.494 (95% CI 1.185–5.247)]，但根据饮酒模式，非潮红者与高血压发病风险增加无关。此外，与非潮红者相比，大量饮酒会增加潮红者患高血压的风险 [HR 2.232 (95% CI 1.054–4.728)]。

结论

在这项为期 12 年的随访研究中，我们观察到中度和重度饮酒与潮红时高血压风险增加有关。特别是，潮红时大量饮酒的模式显着增加了患高血压的风险。