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The Proportion of Tumour-Stroma in Metastatic Lymph Nodes is An Accurately Prognostic Indicator of Poor Survival for Advanced-Stage Colon Cancers
Pathology & Oncology Research ( IF 2.3 ) Pub Date : 2020-07-21 , DOI: 10.1007/s12253-020-00877-1
Mehmet Zengin 1 , Suat Benek 2
Affiliation  

The importance of tumour microenvironment in tumour behaviour has now become clearer. This study aimed to determine the prognostic effect of the proportion of tumour-stroma (PTS) in metastatic lymph nodes of advanced-stage colon cancers (CCs). We investigated PTS in positive lymph nodes of stage III-IV CC patients who underwent surgical treatment between 2004 and 2014. We used a standard approach in methodology. PTS was significantly associated with prognostic factors in the metastatic lymph nodes (perineural invasion [p = 0.031], lymphatic invasion [p = 0.032], invasive margin [p = 0.043], advanced pT [p = 0.020], and margin involvement [p = 0.034]). In addition, the correlations between PTS estimates (R = 0.704 to 0.617, p < 0.001), the reproducibility of the research (Κappa = 0.72–0.68) and the usefulness of the cut-off value (ROC: 50.33%; AUC = 0.752 [0.667–0.857]) were successful. In univariate analysis, 5-year survival was poor for RFS (p < 0.001), OS (p = 0.001) and LR (p = 0.013) in high PTS patients. Multivariate analysis confirmed that high PTS was an independent worse parameter for RFS (HR = 1.32, 95% CI: 1.17–2.55, p = 0.001) and OS (HR = 1.37, 95% CI: 1.25–1 - 2.56, p = 0.009). In this study, we showed that high PTS in metastatic lymph nodes was a successful prognostic marker for advanced-stage CCs. Also, the standard approach we used for the methodology was successful.



中文翻译:

转移性淋巴结中肿瘤间质的比例是晚期结肠癌生存不良的准确预后指标

肿瘤微环境在肿瘤行为中的重要性现已变得更加清楚。本研究旨在确定晚期结肠癌(CC)转移淋巴结中肿瘤基质(PTS)比例的预后作用。我们调查了 2004 年至 2014 年间接受手术治疗的 III-IV 期 CC 患者的阳性淋巴结中的 PTS。我们在方法学上使用了标准方法。 PTS 与转移淋巴结的预后因素显着相关(神经周围浸润 [ p  = 0.031]、淋巴管浸润 [ p  = 0.032]、浸润边缘 [ p  = 0.043]、晚期 pT [ p  = 0.020] 和边缘受累 [ p  = 0.034])。此外,PTS 估计值(R = 0.704 至 0.617,p  < 0.001)、研究的再现性(Κappa = 0.72–0.68)和截止值的有​​用性(ROC:50.33%;AUC = 0.752)之间的相关性[0.667–0.857])是成功的。在单变量分析中, 高 PTS 患者的RFS ( p  < 0.001)、OS ( p  = 0.001) 和 LR ( p = 0.013)的 5 年生存率较差。多变量分析证实,高 PTS 是 RFS(HR = 1.32,95% CI:1.17–2.55, p  = 0.001)和 OS(HR = 1.37,95% CI:1.25–1 - 2.56,p  = 0.009 )的独立较差参数)。在这项研究中,我们证明转移淋巴结中的高 PTS 是晚期 CC 的成功预后标志。此外,我们用于该方法的标准方法也是成功的。

更新日期:2020-07-21
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