Abstract

Two new phenylpropanoids, named stytonkinol A (1) and stytonkinol B (2), have been isolated from the resin of Styrax tonkinensis (Pierre) Craib ex Hartw. Their structures were determined by spectroscopic analysis, including 1D and 2D NMR, and HR-ESI–MS. Two isolated compounds were assayed for cytotoxic activities against five tumor cell lines (HepG-2, A549, Hela, MCF-7, and PC-3) by Cell Counting Kit-8 (CCK-8) test in vitro. The cytotoxic effectiveness observed against Hela, and MCF-7 cell lines of compound 1 were superior or similar to the positive control cisplatin (IC₅₀ values of 40.95 and 47.36 μM), with IC₅₀ values of 26.75 and 45.16 μM, respectively, while it showed moderate cytotoxic activities against the HepG-2 and PC-3 cell lines. Compound 2 showed moderate cytotoxic activities on cells MCF-7 with IC₅₀ values of 57.1 μM.

Graphic abstract

中文翻译：

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来自Styrax tonkinensis（Pierre）Craib ex Hartw的树脂的两种新的苯基丙烷。

摘要

从Styrax tonkinensis（Pierre）Craib ex Hartw的树脂中分离出了两种新的苯丙烷类化合物，分别称为stytonkinol A（1）和stykinkinol B（2）。它们的结构通过光谱分析确定，包括1D和2D NMR以及HR-ESI-MS。通过体外细胞计数试剂盒8（CCK-8）测试，测定了两种分离的化合物对五种肿瘤细胞系（HepG-2，A549，Hela，MCF-7和PC-3）的细胞毒活性。观察到的针对化合物1的Hela和MCF-7细胞系的细胞毒性效果优于或类似于阳性对照顺铂（IC ₅₀值为40.95和47.36μM），IC _50为50值分别为26.75和45.16μM，同时显示出对HepG-2和PC-3细胞系的中等细胞毒活性。化合物2对MCF-7细胞表现出中等的细胞毒活性，IC ₅₀值为57.1μM。

图形摘要