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Synthesis and characterization of pH sensitive hydrogel nanoparticles based on poly(N-isopropyl acrylamide-co-methacrylic acid).
Journal of Materials Science: Materials in Medicine ( IF 4.2 ) Pub Date : 2020-07-21 , DOI: 10.1007/s10856-020-06400-x
C E Belman-Flores 1 , W Herrera-Kao 1 , R F Vargas-Coronado 1 , A May-Pat 1 , A I Oliva 2 , N Rodríguez-Fuentes 3 , H Vázquez-Torres 4 , J V Cauich-Rodríguez 1 , J M Cervantes-Uc 1
Affiliation  

In this work, pH-sensitive hydrogel nanoparticles based on N-isopropyl acrylamide (NIPAM) and methacrylic acid (MAA) at various molar ratios, were synthesized and characterized in terms of physicochemical and biological properties. FTIR and 1HNMR spectra confirmed the successful synthesis of the copolymer that formed nanoparticles. AFM images and FE-SEM micrographs showed that nanoparticles were spherical, but their round-shape was slightly compromised with MAA content; besides, the size of particles tends to decrease as MAA content increased. The hydrogels nanoparticles also exhibited an interesting pH-sensitivity, displaying changes in its particle size when changes in pH media occurred. Biological characterization results indicate that all the synthesized particles are non-cytotoxic to endothelial cells and hemocompatible, although an increase of MAA content leads to a slight increase in the hemolysis percentage. Therefore, the pH-sensitivity hydrogels may serve as a versatile platform as self-regulated drug delivery systems in response to environmental pH changes.



中文翻译:

基于聚(N-异丙基丙烯酰胺-共-甲基丙烯酸)的pH敏感水凝胶纳米粒子的合成与表征。

在这项工作中,合成了基于N-异丙基丙烯酰胺(NIPAM)和甲基丙烯酸(MAA)的pH敏感水凝胶纳米颗粒,并根据其理化和生物学特性对其进行了表征。FTIR和1HNMR光谱证实了形成纳米颗粒的共聚物的成功合成。AFM图像和FE-SEM显微照片显示纳米颗粒为球形,但其圆形形状受MAA含量的影响较小;此外,随着MAA含量的增加,颗粒尺寸趋于减小。水凝胶纳米颗粒还表现出令人感兴趣的pH敏感性,当pH介质发生变化时,其粒径也会发生变化。生物学表征结果表明,尽管MAA含量增加导致溶血百分比略有增加,但所有合成的颗粒均对内皮细胞无细胞毒性且具有血液相容性。因此,pH敏感性水凝胶可作为通用平台,以响应环境pH的变化作为自我调节的药物输送系统。

更新日期:2020-07-21
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