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Nanocomposites of ionic copolymer integrating Gd-containing polyoxometalate as a multiple platform for enhanced MRI and pH-response chemotherapy.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-07-20 , DOI: 10.1039/d0tb00782j Tingting Zhou 1 , Guofeng Wan 1 , Bao Li 1 , Lixin Wu 1
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-07-20 , DOI: 10.1039/d0tb00782j Tingting Zhou 1 , Guofeng Wan 1 , Bao Li 1 , Lixin Wu 1
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This article describes the fabrication of nanosized paramagnetic drug carriers via the assembly of a pH-responsive hydrophilic block copolymer poly(polyethylene glycol methyl ether methacrylate)-b-poly(methacrylic acid-co-trimethyl ammonium bromide propyl methacrylate) (PPMT) and polyoxometalate K13[Gd(β2-SiW11O39)2] (GdSiW11) through electrostatic interaction. Owing to the hydrophilicity, large molecular weight, and high content of the GdSiW11 cluster bearing in the nanocomposites, the organic–inorganic nanocomposite exhibited an impressive longitudinal relaxivity as a contrast agent for magnetic resonance imaging (MRI). The surplus negative charges from the polyoxometalate cluster in the polymer nanocomposites facilitated the capture of the anti-tumor drug doxorubicin (DOX). The DOX-loaded nanocomposites were stable under the physiological environment, whereas a responsive release of DOX was achieved at pH values similar to the tumor microenvironment due to the regulation of the polyoxometalate and carboxyl groups. The DOX-loaded PPMT2–GdSiW11 nanocomposites were observed to enrich effectively at tumor sites through MRI after intravenous injection. Furthermore, the DOX-loaded composites manifested enhanced in vivo anti-tumor therapeutic efficacy and sustainable circulation time of more than 5 h, which were favourable for imaging measurement. With the advantages of the designed composite system, the present experiments propose a strategy for developing a new multiple imaging-drug delivery-local therapy platform for synergistic diagnosis and therapy.
中文翻译：
离子共聚物的纳米复合材料，整合了含Gd的多金属氧酸盐，作为增强MRI和pH响应化疗的多个平台。
本文介绍了通过组装pH响应亲水性嵌段共聚物聚（聚乙二醇甲基醚甲基丙烯酸酯）-b-聚（甲基丙烯酸-共-三甲基溴化铵甲基丙烯酸丙酯）（PPMT）和聚金属氧酸盐制备纳米级顺磁性药物载体的方法ķ 13 [钆（β 2 -SiW 11 ö 39）2 ]（GdSiW 11）通过静电相互作用。由于GdSiW 11的亲水性，大分子量和高含量作为无机复合材料的纳米簇，有机-无机纳米复合材料作为磁共振成像（MRI）的造影剂具有令人印象深刻的纵向弛豫性。来自聚合物纳米复合物中多金属氧酸盐簇的过量负电荷促进了抗肿瘤药物阿霉素（DOX）的捕获。负载有DOX的纳米复合材料在生理环境下是稳定的，但由于多金属氧酸盐和羧基的调节，在类似于肿瘤微环境的pH值下实现了DOX的响应释放。静脉注射后，通过MRI观察到DOX加载的PPMT 2 –GdSiW 11纳米复合材料在肿瘤部位有效富集。此外，DOX加载的复合材料表现出增强的性能。体内的抗肿瘤治疗效果和可持续循环时间超过5 h，这对于影像测量是有利的。利用设计的复合系统的优势，本实验提出了一种策略，用于开发用于协同诊断和治疗的新的多重成像-药物递送-局部治疗平台。
更新日期：2020-08-05
中文翻译：
离子共聚物的纳米复合材料，整合了含Gd的多金属氧酸盐，作为增强MRI和pH响应化疗的多个平台。
本文介绍了通过组装pH响应亲水性嵌段共聚物聚（聚乙二醇甲基醚甲基丙烯酸酯）-b-聚（甲基丙烯酸-共-三甲基溴化铵甲基丙烯酸丙酯）（PPMT）和聚金属氧酸盐制备纳米级顺磁性药物载体的方法ķ 13 [钆（β 2 -SiW 11 ö 39）2 ]（GdSiW 11）通过静电相互作用。由于GdSiW 11的亲水性，大分子量和高含量作为无机复合材料的纳米簇，有机-无机纳米复合材料作为磁共振成像（MRI）的造影剂具有令人印象深刻的纵向弛豫性。来自聚合物纳米复合物中多金属氧酸盐簇的过量负电荷促进了抗肿瘤药物阿霉素（DOX）的捕获。负载有DOX的纳米复合材料在生理环境下是稳定的，但由于多金属氧酸盐和羧基的调节，在类似于肿瘤微环境的pH值下实现了DOX的响应释放。静脉注射后，通过MRI观察到DOX加载的PPMT 2 –GdSiW 11纳米复合材料在肿瘤部位有效富集。此外，DOX加载的复合材料表现出增强的性能。体内的抗肿瘤治疗效果和可持续循环时间超过5 h，这对于影像测量是有利的。利用设计的复合系统的优势，本实验提出了一种策略，用于开发用于协同诊断和治疗的新的多重成像-药物递送-局部治疗平台。
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