Hyperlipidemia represents a major risk factor for cardiovascular diseases leading to myocardial injury. The present study aimed to illustrate the myocardial injury induced in a diabetic hyperlipidemic rat model and the effect of vitamin D3, 10-DHGD intake either individually or in combination form. Male albino rats were selected for the study, received alloxan, hypercholesterolemic diet, and categorized into four groups. The first one (DHC), received hypercholesterolemic diet only and referred to as control. The remaining groups (2, 3, 4) received vitamin D3, 10-DHGD, and combination of both, respectively. Certain biomarkers that were selected for MI evaluation included blood glucose, lipogram pattern, Copeptin, C-reactive protein, myeloperoxidase, heart fatty acid-binding protein, and histopathological changes in myocardium and aorta. Vitamin D3 and 10-DHGD intake induced significant hypoglycemic, hypolipidemic effects, decreased inflammation, and MI biomarkers. Decreased myocardial vacuoles, foam cells, and intimal lesions were also observed compared to DHC. Their combination intake induced more marked reduction in all biomarkers and showed a histopathological pattern similar to normal features of myocardium and aorta. Our findings suggest the therapeutic roles of vitamin D3, 10-DHGD, and their combination against myocardial injury in diabetic hyperlipidemic rats.

Impact statement

Hyperlipidemia represents a major risk factor for cardiovascular diseases leading to myocardial injury (MI). The present study aimed to illustrate the pattern of myocardial injury induced in diabetic hyperlipidemic rat model and the effect of vitamin D3, 10-dehydrogingerdione (10-DHGD) intake either individually or in combination form.

中文翻译：

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糖尿病高脂血症大鼠早期心肌损伤生物标志物：10-脱氢姜二酮和维生素 D3 的影响。

高脂血症是导致心肌损伤的心血管疾病的主要危险因素。本研究旨在说明糖尿病高脂血症大鼠模型中诱导的心肌损伤以及维生素 D3、10-DHGD 单独或联合摄入的影响。选择雄性白化大鼠进行研究，接受四氧嘧啶、高胆固醇饮食，并分为四组。第一个 (DHC)，仅接受高胆固醇饮食并称为对照。其余组（2、3、4）分别接受维生素 D3、10-DHGD 和两者的组合。选择用于 MI 评估的某些生物标志物包括血糖、脂肪图模式、和肽素、C 反应蛋白、髓过氧化物酶、心脏脂肪酸结合蛋白以及心肌和主动脉的组织病理学变化。维生素 D3 和 10-DHGD 摄入会导致显着的低血糖、降血脂作用、炎症减少和 MI 生物标志物。与 DHC 相比，还观察到心肌空泡、泡沫细胞和内膜病变减少。他们的组合摄入导致所有生物标志物的更显着减少，并显示出与心肌和主动脉的正常特征相似的组织病理学模式。我们的研究结果表明维生素 D3、10-DHGD 及其组合对糖尿病高脂血症大鼠心肌损伤的治疗作用。他们的组合摄入导致所有生物标志物的更显着减少，并显示出与心肌和主动脉的正常特征相似的组织病理学模式。我们的研究结果表明维生素 D3、10-DHGD 及其组合对糖尿病高脂血症大鼠心肌损伤的治疗作用。他们的组合摄入导致所有生物标志物的更显着减少，并显示出与心肌和主动脉的正常特征相似的组织病理学模式。我们的研究结果表明维生素 D3、10-DHGD 及其组合对糖尿病高脂血症大鼠心肌损伤的治疗作用。

影响陈述

高脂血症是导致心肌损伤 (MI) 的心血管疾病的主要危险因素。本研究旨在说明糖尿病高脂血症大鼠模型中诱导的心肌损伤模式以及维生素 D3、10-脱氢姜二酮 (10-DHGD) 单独或联合摄入的影响。