Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of information to include in publications describing in vivo experiments to enable others to scrutinise the work adequately, evaluate its methodological rigour and reproduce the methods and results. Despite considerable levels of endorsement by funders and journals over the years, adherence to the guidelines has been inconsistent, and the anticipated improvements in the quality of reporting in animal research publications have not been achieved. Here, we introduce ARRIVE 2.0. The guidelines have been updated and information reorganised to facilitate their use in practice. We used a Delphi exercise to prioritise and divide the items of the guidelines into two sets, the ‘ARRIVE Essential 10’, which constitutes the minimum requirement, and the ‘Recommended Set’, which describes the research context. This division facilitates improved reporting of animal research by supporting a stepwise approach to implementation. This helps journal editors and reviewers verify that the most important items are being reported in manuscripts. We have also developed the accompanying Explanation and Elaboration document, which serves (1) to explain the rationale behind each item in the guidelines, (2) to clarify key concepts and (3) to provide illustrative examples. We aim, through these changes, to help ensure that researchers, reviewers and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility.

中文翻译：

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ARRIVE 指南 2.0：更新的动物研究报告指南

可重复的科学需要透明的报告。ARRIVE 指南（动物研究：体内实验报告）最初于 2010 年制定，旨在改进动物研究的报告。它们包含一份信息清单，包含在描述体内实验的出版物中，使其他人能够充分审查这项工作，评估其方法的严谨性并重现方法和结果。尽管多年来资助者和期刊给予了相当大的认可，但对指南的遵守情况却不一致，并且动物研究出版物报告质量的预期改进尚未实现。在这里，我们介绍ARRIVE 2.0。该指南已更新并重新组织了信息，以方便其在实践中的使用。我们使用 Delphi 练习对指南的项目进行优先级排序并将其分为两组，“ARRIVE Essential 10”（构成最低要求）和“推荐组”（描述研究背景​​）。该部门通过支持逐步实施的方法来促进动物研究报告的改进。这有助于期刊编辑和审稿人验证手稿中是否报告了最重要的项目。我们还制定了随附的解释和阐述文件，其作用是 (1) 解释指南中每个项目背后的基本原理，(2) 阐明关键概念，以及 (3) 提供说明性示例。我们的目标是通过这些变革，帮助确保研究人员、审稿人和期刊编辑能够更好地提高科学过程的严谨性和透明度，从而提高可重复性。