Thirteen carneic acids were isolated from the fungal endophyte Phomopsis sp. SNB-LAP1-7-32. Their structures were identified by mass spectrometry and extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. Compounds 1–13 were investigated for their antipolymerase activities against DENV polymerase and Zika NS5. Five of them exhibited significant inhibition of dengue polymerase with IC₅₀ values in the 10 to 20 μM range without cytotoxicity. None inhibited Zika virus NS5 protein.

中文翻译：

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来自内生拟茎点菌属的 Carneic Acids。作为登革病毒聚合酶抑制剂。

从真菌内生菌Phomopsis sp.中分离出 13 种鼠尾草酸。SNB-LAP1-7-32。它们的结构是通过质谱和广泛的一维和二维核磁共振光谱以及与文献中报道的数据进行比较来确定的。化合物1 - 13进行了调查针对登革病毒聚合酶和兹卡NS5他们antipolymerase活动。其中五个表现出对登革热聚合酶的显着抑制，IC ₅₀值在 10 到 20 μM 范围内，没有细胞毒性。没有一种抑制寨卡病毒 NS5 蛋白。