Individuals with migraine generally experience photophobia and/or phonophobia during and between migraine attacks. Many different mechanisms have been postulated to explain these migraine phenomena including abnormal patterns of connectivity across the cortex. The results, however, remain contradictory and there is no clear consensus on the nature of the cortical abnormalities in migraine. Here, we uncover alterations in cortical patterns of coherence (connectivity) in interictal migraineurs during the presentation of visual and auditory stimuli, as well as at rest, to capitalize on the sensory sensitivities that are characteristic of migraine, and to reconcile the conflicting literature on migraine cortical connectivity. We used a high-density electroencephalography (HD-EEG) system, with 128 customized electrode locations, to measure inter- and intra-hemispheric coherence from 17 individuals with migraine (12 female) in the interictal period, and 18 age- and gender-matched healthy control subjects, during visual (vertical grating pattern) and auditory (modulated tone) stimulation which varied in temporal frequency (4 and 6Hz), and during rest. To ensure that participants were attending, participants performed a color detection task at fixation. Analyses of the EEG signal included characterizing the inter- and intra-hemisphere coherence between the scalp EEG channels over 2-second time intervals and over different frequency bands at different spatial distances and spatial clusters, and Pearson's correlation coefficients (PCCs) were estimated at zero-lag. Repeated measures (between-group) analyses-of-variance with post hoc multiple comparison correction were conducted. Relative to controls, migraineurs exhibited significantly (i) faster color detection performance; (ii) lower long-distance spatial coherence of alpha-band activity during both evoked conditions, regardless of the stimulation frequency; (iii) lower coherence between the right frontal cluster and all clusters in the left hemisphere (inter-hemisphere coherence) during 4Hz auditory and visual stimulation; and (iv) lower long-distance coherence (in all frequency bands) between the right occipito-parietal cluster and all other clusters during the (4Hz and 6Hz) visual stimuli. No significant group differences were observed in the resting state data. The abnormal patterns of EEG coherence in interictal migraineurs during visual and auditory stimuli may be associated with cortical hyper-excitability in migraineurs.

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使用超高密度脑电图检测到的间质性偏头痛的皮层相干性异常

偏头痛患者通常在偏头痛发作期间和发作之间会发生畏光和/或恐惧症。推测有许多不同的机制来解释这些偏头痛现象，包括整个皮质的异常连接模式。然而，结果仍然是矛盾的，并且对于偏头痛的皮质异常的性质尚无明确共识。在这里，我们发现在视觉和听觉刺激以及静息期间，发作性偏头痛患者的皮层连贯性（连接性）的变化，以利用偏头痛特有的感官敏感性，并调和了有关偏头痛的相关文献。偏头痛皮质连通性。我们使用了具有128个自定义电极位置的高密度脑电图（HD-EEG）系统，在视觉（垂直光栅模式）和听觉（调制音调）刺激下，测量间隔期的17名偏头痛患者（12名女性）以及18名年龄和性别匹配的健康对照受试者的半球和半球内一致性暂时频率（4和6Hz）以及休息时变化。为了确保参与者参加，参与者在注视时执行了颜色检测任务。脑电信号分析包括表征2秒时间间隔内，不同空间距离和空间簇上不同频段的头皮脑电通道之间的半球间和半球内相干性，皮尔逊相关系数（PCC）估计为零-落后。使用事后多重比较校正进行重复测量（组间）方差分析。相对于对照，偏头痛具有明显的表现：（i）更快的颜色检测性能；（ii）在两种诱发条件下，无论刺激频率如何，阿尔法带活动的远距离空间相干性都较低；（iii）在4Hz听觉和视觉刺激下，右额叶簇与左半球所有簇之间的相干性较低（半球间相干性）；（iv）在（4Hz和6Hz）视觉刺激过程中，右枕骨顶簇和所有其他簇之间的长距离相干性降低（在所有频带中）。在静息状态数据中未观察到显着的组差异。