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Comparative genomics and transcriptomics of 4 Paragonimus species provide insights into lung fluke parasitism and pathogenesis.
GigaScience ( IF 11.8 ) Pub Date : 2020-07-20 , DOI: 10.1093/gigascience/giaa073
Bruce A Rosa 1 , Young-Jun Choi 1 , Samantha N McNulty 2 , Hyeim Jung 1 , John Martin 1 , Takeshi Agatsuma 3 , Hiromu Sugiyama 4 , Thanh Hoa Le 5 , Pham Ngoc Doanh 6, 7 , Wanchai Maleewong 8, 9 , David Blair 10 , Paul J Brindley 11 , Peter U Fischer 1 , Makedonka Mitreva 1, 2
Affiliation  

Paragonimus spp. (lung flukes) are among the most injurious foodborne helminths, infecting ∼23 million people and subjecting ∼292 million to infection risk. Paragonimiasis is acquired from infected undercooked crustaceans and primarily affects the lungs but often causes lesions elsewhere including the brain. The disease is easily mistaken for tuberculosis owing to similar pulmonary symptoms, and accordingly, diagnostics are in demand.

中文翻译:


4 种并殖吸虫属物种的比较基因组学和转录组学为了解肺吸虫寄生和发病机制提供了见解。



并殖吸虫属(肺吸虫)是危害性最大的食源性蠕虫之一,感染约 2,300 万人,并使约 2.92 亿人面临感染风险。并殖吸虫病是从受感染的未煮熟的甲壳类动物获得的,主要影响肺部,但通常会引起包括大脑在内的其他部位的病变。由于肺部症状相似,这种疾病很容易被误认为是结核病,因此需要进行诊断。
更新日期:2020-07-20
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